INT233010

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 6.04
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (PERP) Golgi apparatus (PERP) nucleolus (PERP)
plasma membrane (PERP) nucleus (PERP) cytoplasm (PERP)
Anatomy Link Frequency
keratinocytes 3
thyroid 1
endothelial cells 1
superior 1
PERP (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 141 100.00 Very High Very High Very High
rheumatoid arthritis 225 91.44 High High
Osteoarthritis 81 86.32 High High
antagonist 24 65.76 Quite High
Pain 6 61.84 Quite High
Inflammation 12 55.40 Quite High
positron emission tomography 21 52.12 Quite High
cytokine 3 12.16 Low Low
medulla 7 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 225 100.00 Very High Very High Very High
Mesothelioma 4 99.72 Very High Very High Very High
Adenocarcinoma 46 99.20 Very High Very High Very High
Metastasis 61 95.36 Very High Very High Very High
Rheumatoid Arthritis 225 91.44 High High
Malignant Neoplastic Disease 14 87.72 High High
Osteoarthritis 81 86.32 High High
Cancer 130 84.44 Quite High
Thyroid Neoplasm 96 82.32 Quite High
Renal Cancer 8 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of the randomized trials (Taieb et al 2008) compared subjects who all received 3.7 GBq (100 mCi) 131I after rhTSH preparation or THW.
Gene_expression (preparation) of THW associated with withdrawal
1) Confidence 0.26 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 0 Pain Relevance 0.23
Considering rhTSH RAI scans in both arms, 93% of 220 evaluable scans after rhTSH were concordant with or superior to those done under THW (p = 0.108).
Gene_expression (scans) of THW in superior associated with withdrawal
2) Confidence 0.26 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 0.32 Pain Relevance 0.17
In summary, data on almost 600 patients have been reported in several uncontrolled studies and two relatively small randomized controlled trials, demonstrating that rhTSH stimulation for RAI thyroid remnant ablation is successful in about 80% to 90% of patients, comparable to rates seen with THW preparation.
Gene_expression (preparation) of THW in thyroid associated with withdrawal
3) Confidence 0.26 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 0.90 Pain Relevance 0.09
Adrenomedullin also induces the expression of adhesion molecules (intercellular adhesion molecule, or ICAM; and endothelial selectin, or E-selectin) at the surface of HUVECs [17] and human oral keratinocytes [18].
Gene_expression (expression) of keratinocytes in keratinocytes associated with adhesions
4) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.87 Pain Relevance 0.67
Adrenomedullin also increases the expression of adhesion molecules in endothelial cells and keratinocytes.
Gene_expression (expression) of keratinocytes in keratinocytes associated with adhesions
5) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991025 Disease Relevance 0.76 Pain Relevance 0.25
Adrenomedullin also increases the expression of adhesion molecules in endothelial cells and keratinocytes.
Gene_expression (expression) of keratinocytes in endothelial cells associated with adhesions
6) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991025 Disease Relevance 0.76 Pain Relevance 0.25
In contrast to most adenocarcinomas, epithelial mesotheliomas consistently express keratinocyte-type keratins, notably K5, in addition to keratins K8, K18, K19, and K7 typical for simple epithelia (Moll et al. 1989; Ordonez 1998; Chu and Weiss 2002a; Yaziji et al. 2006).
Gene_expression (express) of keratinocyte-type in keratinocyte associated with adenocarcinoma and mesothelioma
7) Confidence 0.01 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.43 Pain Relevance 0

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