INT233113

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 2008
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 24
Total Number 28
Disease Relevance 18.08
Pain Relevance 13.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm8) transmembrane transport (Trpm8)
Anatomy Link Frequency
neurons 3
nerve 1
colon 1
skin 1
lung 1
Trpm8 (Mus musculus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 20 100.00 Very High Very High Very High
Spontaneous pain 37 99.70 Very High Very High Very High
allodynia 192 99.60 Very High Very High Very High
Pain 989 99.56 Very High Very High Very High
dorsal root ganglion 250 99.48 Very High Very High Very High
induced neuropathy 36 99.38 Very High Very High Very High
trigeminal ganglion 164 98.92 Very High Very High Very High
fifth nerve 6 98.68 Very High Very High Very High
TRP channel 99 98.16 Very High Very High Very High
Kinase C 42 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 989 99.70 Very High Very High Very High
Neuropathic Pain 670 99.60 Very High Very High Very High
Nervous System Injury 194 99.56 Very High Very High Very High
Targeted Disruption 193 99.50 Very High Very High Very High
Hypersensitivity 260 99.24 Very High Very High Very High
Sprains And Strains 778 99.08 Very High Very High Very High
Ganglion Cysts 520 99.00 Very High Very High Very High
Cancer 33 98.48 Very High Very High Very High
Pruritus 102 97.96 Very High Very High Very High
Hyperalgesia 261 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Menthol is a small and fairly lipophilic compound which easily partitions in the lipid bilayer and could thus be expected to affect TRPM8 channel function from various interaction sites.
Regulation (affect) of TRPM8
1) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0.14 Pain Relevance 0.16
In further support of this conclusion, modulation of TRPM8 activity by pH has differential effects on activation by icilin and cold, versus menthol.
Regulation (modulation) of TRPM8
2) Confidence 0.58 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0
As has been noted, TRPM8 is a thermally regulated channel activated by moderately cool temperatures (<23–28°C) and by compounds that evoke a sensation of coolness, such as menthol, eucalyptol, and icilin.
Regulation (regulated) of TRPM8
3) Confidence 0.58 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.40 Pain Relevance 0.17
TRPM8 is a thermally regulated channel activated by moderately cool temperatures (<23-28°C) and by agents that evoke a sensation of coolness, such as menthol, eucalyptol, and icilin.
Regulation (regulated) of TRPM8
4) Confidence 0.58 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.06 Pain Relevance 0
subunit Scn11a correlated with levels of spontaneous pain behavior, and regulation of the cool receptor Trpm8 correlated with heat hypersensibility.
Regulation (regulation) of Trpm8 associated with pain and spontaneous pain
5) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.89 Pain Relevance 0.51
A significant negative across strains correlation was seen between the degree of down-regulation of Trpm8 and heat allodynia (rS = -0.98, p = 0.005; rP = -0.90, p = 0.04).
Regulation (regulation) of Trpm8 associated with allodynia and sprains and strains
6) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.08 Pain Relevance 0.41
However, using the same model, another study reported down-regulation of both TRPA1 and TRPM8 in injured neurons and no change in expression in the uninjured ganglion [39].
Regulation (regulation) of TRPM8 in neurons associated with ganglion cysts
7) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.95 Pain Relevance 0.64
Cisplatin and oxaliplatin induced up-regulation of TRPV1, TRPM8 and TRPA1 mRNA in vitro
Regulation (regulation) of TRPM8
8) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.97 Pain Relevance 0.64
Cisplatin also induced up-regulation of TRPM8 mRNA (2 and 4 fold, respectively) at 24 h and 48 h (Figure 2B).
Regulation (regulation) of TRPM8 mRNA
9) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.21 Pain Relevance 0.20
First, we demonstrate that treatment with platinum drugs results in the up-regulation of TRPV1, TRPA1, and TRPM8 mRNA in cultured dorsal root ganglion (DRG) neurons and that a similar up-regulation occurs with TRPV1 and TRPA1 following in vivo treatment with cisplatin although cisplatin-treated mice had no change in the proportion of TRPV1-immunopositive TG neurons.
Regulation (regulation) of TRPM8 mRNA in neurons associated with ganglion cysts and dorsal root ganglion
10) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.90 Pain Relevance 0.61
In this study, we used models of cisplatin and oxaliplatin-induced neuropathy to investigate whether TRPV1, TRPM8, and TRPA1 mRNA expression were altered along with changes in thermal sensitivity observed in chemotherapeutic neuropathy.
Spec (whether) Regulation (altered) of TRPM8 associated with induced neuropathy and neuropathic pain
11) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 1.15 Pain Relevance 0.70
The greater the down-regulation of Trpm8 the less the heat allodynia.
Regulation (regulation) of Trpm8 associated with allodynia
12) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.07 Pain Relevance 0.42
A recent strategy to generate transgenic mice with GFP under the control of TRPM8 promotor has good potential to study distribution and function in its physiology and pathology [210].
Regulation (control) of TRPM8 promotor associated with targeted disruption
13) Confidence 0.34 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.65 Pain Relevance 0.52
TRPA1 mRNA expression is completely absent from P14 ret mutant DRG, whereas mRNAs for TRPV1 and TRPM8 appear unaffected.
Neg (unaffected) Spec (appear) Regulation (unaffected) of TRPM8
14) Confidence 0.28 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.36
The ability of LPC to induce cold hypersensitivity in vivo supports a role for iPLA2 in modulating TRPM8.
Regulation (modulating) of TRPM8 associated with hypersensitivity
15) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.44 Pain Relevance 0.11
Our earlier studies also demonstrated that endogenous lysophospholipids (LPLs) generated by the calcium-independent form of the enzyme phospholipase A2 (iPLA2) regulated TRPM8 activity [6].
Regulation (regulated) of TRPM8
16) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.24 Pain Relevance 0.13
Earlier studies showed that the activity of TRPM8 was modulated by the activity of a sub-type of phospholipase A2, namely iPLA2 [6,34].
Regulation (modulated) of TRPM8
17) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.36 Pain Relevance 0.16
Correlational analysis based on in situ hybridization provided evidence that differential regulation of Scn11a and Trpm8 contributes to across-strain variability in pain phenotype.
Regulation (regulation) of Trpm8 associated with pain and sprains and strains
18) Confidence 0.26 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2649910 Disease Relevance 1.13 Pain Relevance 0.76
subunit Scn11a correlated with levels of spontaneous pain behavior, and regulation of the cool receptor Trpm8 correlated with heat hypersensibility.
Regulation (regulation) of Trpm8 associated with pain and spontaneous pain
19) Confidence 0.23 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2649910 Disease Relevance 1.31 Pain Relevance 0.85
This specificity difference is reflected by the fact that TRPM8+ neurons are unaffected in Wood's ablation experiment [39], whereas TRPM8 expression was absent in Runx1 L-CKO mice using Kuner's Nav1.8Cre line (Fig. 1B).
Neg (unaffected) Regulation (unaffected) of TRPM8 in neurons
20) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.97 Pain Relevance 1.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox