INT233130

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.69
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PKN1) signal transduction (PKN1) histone binding (PKN1)
plasma membrane (PKN1) nucleus (PKN1) intracellular (PKN1)
Anatomy Link Frequency
cholinergic neurons 1
ear 1
PKN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 150 95.36 Very High Very High Very High
cerebral cortex 7 91.00 High High
Neurotransmitter 6 61.68 Quite High
Anterior cingulate cortex 3 50.68 Quite High
antagonist 9 44.16 Quite Low
Central nervous system 3 23.52 Low Low
Spinal cord 3 19.56 Low Low
positron emission tomography 15 14.72 Low Low
Neurobehavioral 9 5.00 Very Low Very Low Very Low
Limbic system 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 312 100.00 Very High Very High Very High
Cognitive Disorder 57 79.36 Quite High
Convulsion 5 35.60 Quite Low
Stress 12 5.00 Very Low Very Low Very Low
Depression 9 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 5 5.00 Very Low Very Low Very Low
Dyssomnias 3 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Hallucination 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Figure 16A the MIP is given the cut separating the grandmother element n1 from its inputs. ??
Regulation (separating) of n1
1) Confidence 0.02 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
This conclusion is further supported by the observation that both N1 and P300 are influenced by noradrenergic, dopaminergic, and cholinergic systems, i.e., systems which are known to mediate attention and arousal [81, 82].


Regulation (influenced) of N1
2) Confidence 0.00 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.24 Pain Relevance 0.03
However, N1 is not a purely sensory phenomenon but is affected by attention, e.g., the amplitude of the auditory N1 can be increased by simply asking participants to attend to one ear [68, 69] or by administering a small dose of caffeine [70, 71].
Neg (not) Regulation (affected) of N1 in ear
3) Confidence 0.00 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.23 Pain Relevance 0
The effects of SD on N1 and P300 could thus be an effect of reduced cortical ACh levels caused by inhibition of the cholinergic neurons by AD.
Regulation (effects) of N1 in cholinergic neurons associated with adenocard and sleep disorders
4) Confidence 0.00 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.22 Pain Relevance 0.15

General Comments

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