INT23317

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Context Info
Confidence 0.48
First Reported 1985
Last Reported 2010
Negated 5
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 14.51
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spn)
Anatomy Link Frequency
pancreas 2
SPN 2
sympathetic 2
dorsal 1
bladder 1
Spn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 27 100.00 Very High Very High Very High
Enkephalin 16 100.00 Very High Very High Very High
substance P 8 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
Dorsal horn 24 98.28 Very High Very High Very High
Calcitonin gene-related peptide 36 97.76 Very High Very High Very High
imagery 26 96.84 Very High Very High Very High
Nerve growth factor 79 93.60 High High
Somatostatin 4 92.76 High High
Pain 14 90.48 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 160 100.00 Very High Very High Very High
Rhinitis 1 99.40 Very High Very High Very High
Cancer 117 98.98 Very High Very High Very High
Increased Venous Pressure Under Development 30 98.72 Very High Very High Very High
Diffuse Large B-cell Lymphoma 5 97.52 Very High Very High Very High
Body Weight 2 97.48 Very High Very High Very High
Infection 11 96.54 Very High Very High Very High
Weight Loss 6 95.72 Very High Very High Very High
Malignant Neoplastic Disease 25 95.04 Very High Very High Very High
Empyema Thoracis 5 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Within the LSn, antisera against dynorphin 1-8 (DYN), substance P (SP), and Met-enkephalin (ENK) produced labeling of a large number of processes in all segmental levels examined.
Gene_expression (produced) of LSn in LSn associated with dynorphin, enkephalin and substance p
1) Confidence 0.48 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 2410576 Disease Relevance 0 Pain Relevance 0.31
In pulpitis, immune cells such as CD43+ granulocytes and CD4+ lymphocytes expressed Y1R.
Gene_expression (granulocytes) of CD43 in granulocytes
2) Confidence 0.42 Published 2010 Journal Int Endod J Section Body Doc Link 20536577 Disease Relevance 0.07 Pain Relevance 0
Sympathetic preganglionic neurons (SPN) coexpress the acetylcholine (ACh)-synthesizing enzyme choline acetyltransferase and different peptides in their cell bodies, but can express them independently in separate varicosities, indicating that SPN segregate transmitters to different synapses.
Gene_expression (coexpress) of SPN in SPN associated with urological neuroanatomy and increased venous pressure under development
3) Confidence 0.26 Published 2009 Journal Neuroscience Section Abstract Doc Link 19524025 Disease Relevance 0.50 Pain Relevance 0.07
Sympathetic preganglionic neurons (SPN) coexpress the acetylcholine (ACh)-synthesizing enzyme choline acetyltransferase and different peptides in their cell bodies, but can express them independently in separate varicosities, indicating that SPN segregate transmitters to different synapses.
Gene_expression (express) of SPN in Sympathetic associated with urological neuroanatomy and increased venous pressure under development
4) Confidence 0.22 Published 2009 Journal Neuroscience Section Abstract Doc Link 19524025 Disease Relevance 0.58 Pain Relevance 0.13
0.01) increased in the LDH, in the DCM, in the region of the SPN and LCP, through which bladder afferent fibers project to the SPN (Fig. 7D–F).
Gene_expression (project) of SPN in bladder associated with dorsal horn and urological neuroanatomy
5) Confidence 0.21 Published 2007 Journal BMC Physiol Section Body Doc Link PMC2000875 Disease Relevance 0.48 Pain Relevance 1.09
We studied in the cell bodies and axon processes of the rat SPN the expression and the proportional coexpression of the vesicular ACh transporter-like immunoreactivity (VAChT), a specific marker of cholinergic synaptic vesicles or ChAT-like immunoreactivity (ChAT), and the peptide methionine enkephalin-like immunoreactivity (mENK), and confirmed the presence of a population of SPN peptidergic, noncholinergic varicosities.
Gene_expression (expression) of SPN in synaptic vesicles associated with urological neuroanatomy, enkephalin and increased venous pressure under development
6) Confidence 0.20 Published 2009 Journal Neuroscience Section Abstract Doc Link 19524025 Disease Relevance 0.78 Pain Relevance 0.17
Three days after virus infection, PRV-IR cells were discovered dorsal to the more ventrally located preganglionic neurons (PRV-IR neurons were commonly seen to lie just dorsal to the preganglionic ChAT-IR neurons in the SPN).
Gene_expression (neurons) of SPN in dorsal associated with urological neuroanatomy and infection
7) Confidence 0.18 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615335 Disease Relevance 0.93 Pain Relevance 0.03
The patients in whom a preoperative diagnosis of SPN of the pancreas was made were studied separately to identify the clinical and imaging characteristics that led to the diagnosis.
Gene_expression (diagnosis) of SPN in pancreas associated with urological neuroanatomy and imagery
8) Confidence 0.10 Published 2007 Journal World J Surg Section Body Doc Link PMC2813543 Disease Relevance 1.17 Pain Relevance 0.10
Preserving surgery for SPN of the pancreas is advocated by one other study in the literature.8 The role of more limited surgery in the form of neoplasm enucleation is uncertain, and there are only case reports of management of SPN by this approach.9 Enucleation was not preformed in the present study because of the high risk of pancreatic fistula.17,18
Gene_expression (Preserving) of SPN in pancreas associated with cancer, pancreatic fistula and urological neuroanatomy
9) Confidence 0.10 Published 2007 Journal World J Surg Section Body Doc Link PMC2813543 Disease Relevance 1.34 Pain Relevance 0.12
Contrary to Dale's principle, our results suggest that SPN can synthesize ChAT and peptides in their cell bodies and route them to distinct axon boutons or terminals in sympathetic ganglia.
Gene_expression (synthesize) of SPN in ganglia associated with urological neuroanatomy
10) Confidence 0.08 Published 2006 Journal Synapse Section Abstract Doc Link 16786529 Disease Relevance 0.38 Pain Relevance 0.43
To explore coexpression of ChAT and neuropeptides in somata and axon processes of SPN, we investigated, using immunohistochemistry, retrograde labeling, confocal analysis, and tridimensional reconstruction, whether ChAT and the peptides neurotensin, methionine-ENK, somatostatin, calcitonin gene-related peptide, and vasoactive intestinal peptide colocalize in somata, axons fibers, and boutons of cat SPN.
Gene_expression (coexpression) of SPN in SPN associated with somatostatin, neuropeptide, urological neuroanatomy, enkephalin and calcitonin gene-related peptide
11) Confidence 0.06 Published 2006 Journal Synapse Section Abstract Doc Link 16786529 Disease Relevance 0.34 Pain Relevance 0.56
Cholinergic sympathetic preganglionic neurons (SPN) coexpress the biosynthetic enzyme for acetylcholine, choline acetyl-transferase (ChAT), and neuropeptides such as enkephalin (ENK) in their cell bodies.
Gene_expression (coexpress) of SPN in sympathetic associated with neuropeptide, urological neuroanatomy and enkephalin
12) Confidence 0.06 Published 2006 Journal Synapse Section Abstract Doc Link 16786529 Disease Relevance 0.17 Pain Relevance 0.47
These cells exhibited medium-sized round nuclei with central nucleoli and eosinophilic cytoplasm, and were strongly positive for myeloperoxidase, CD68, lysozyme, CD45, CD117 (c-kit protein) and CD43.
Gene_expression (positive) of CD43 associated with rhinitis
13) Confidence 0.05 Published 2006 Journal APMIS Section Abstract Doc Link 16948823 Disease Relevance 1.23 Pain Relevance 0.20
These neoplastic cells expressed CD30, CD43, granzyme B and T-cell intracellular antigen-1, but not ALK1, CD3, CD20, CD45, CD79a, cytokeratin, and EMA.
Neg (not) Gene_expression (expressed) of CD43 in T-cell
14) Confidence 0.04 Published 2001 Journal Pathol. Res. Pract. Section Abstract Doc Link 11569930 Disease Relevance 0.40 Pain Relevance 0.09
The cells were immunopositive for CD20, BCL-2, and BCL-6 but negative for CD3 and CD43.
Neg (negative) Gene_expression (negative) of CD43
15) Confidence 0.04 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC2905343 Disease Relevance 0.64 Pain Relevance 0
Immunohistochemical stains on paraffin-embedded tissue showed that the neoplastic cells expressed terminal deoxynucleotidyl transferase, CD43, vimentin, and CD99 (MIC2 gene product) in all cases.
Gene_expression (expressed) of CD43
16) Confidence 0.03 Published 1998 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 9669342 Disease Relevance 0.99 Pain Relevance 0.09
The tumor cells were positive for CD20, CD16, and TIA-1 but negative for CD79a, CD45RO, CD43, CD3, and CD56.
Neg (negative) Gene_expression (negative) of CD43 associated with cancer
17) Confidence 0.02 Published 2005 Journal Virchows Arch. Section Abstract Doc Link 16021507 Disease Relevance 1.37 Pain Relevance 0.08
Flowcytometric analysis revealed a B cell population expressing CD19, CD20, CD22, CD10(dim), surface IgG, HLA-DR and CD43, but negative for CD5, CD34, and tdT.
Neg (negative) Gene_expression (expressing) of CD43 in B cell
18) Confidence 0.02 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 1.05 Pain Relevance 0.07
Immunostaining results for CD20, CD79a, CD43, CD5, sIgM(?
Gene_expression (sIgM) of CD43
19) Confidence 0.01 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2853553 Disease Relevance 0.71 Pain Relevance 0
The cells express relatively intense surface immunoglobulin M (IgM) and/or immunoglobulin D (IgD) and are usually positive for CD5, FMC7 and CD43, but negative for CD10 and BCL6.
Neg (negative) Gene_expression (positive) of CD43
20) Confidence 0.01 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2853553 Disease Relevance 1.36 Pain Relevance 0

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