INT233217

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 0.98
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgb3) plasma membrane (Itgb3)
Anatomy Link Frequency
uterine 2
endometrium 2
uterus 1
Platelets 1
Itgb3 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 14 83.96 Quite High
noradrenaline 1 58.40 Quite High
cva 31 46.44 Quite Low
withdrawal 2 43.20 Quite Low
Versed 6 24.84 Low Low
endometriosis 14 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 15 86.36 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 14 85.92 High High
Cancer 206 84.64 Quite High
Dislocations 14 83.28 Quite High
Targeted Disruption 12 76.88 Quite High
Carcinoma 14 75.68 Quite High
Critical Illness 6 50.00 Quite Low
Anaemia 14 47.60 Quite Low
Hemorrhage 15 46.44 Quite Low
Leukemia 70 42.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelets were gated on the basis of light scatter and CD61 expression.
Gene_expression (expression) of CD61 in Platelets
1) Confidence 0.75 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0 Pain Relevance 0.03
The sum of cell stained scores and intensity scores was calculated to quantify the expression of Itgb3.


Gene_expression (expression) of Itgb3
2) Confidence 0.52 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Effect of Meis1 on Itgb3 expression in the murine uterus
Gene_expression (expression) of Itgb3 in uterus
3) Confidence 0.52 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
To investigate a possible connection between Meis1 and Hoxa10 function in murine uterine development and embryonic implantation, we evaluated the effect of Meis1 expression manipulation on Itgb3 expression.
Gene_expression (expression) of Itgb3 in uterine
4) Confidence 0.52 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
For the experiments studying the effect of MEIS1 expression manipulation on Itgb3 expression, 25 mice each were transfected with pcDNA4/MEIS1, empty pcDNA4, pTER/Meis1 siRNA construct or non-targeting pTER, respectively (100 mice in total).
Gene_expression (expression) of Itgb3
5) Confidence 0.52 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.08 Pain Relevance 0.08
HOXA10 has been demonstrated to be involved in the regulation of pinopode development and expression of other genes involved in endometrial development such as ITGB3 and EMX2 (Bagot et al., 2001; Daftary et al., 2002; Troy et al., 2003).
Gene_expression (expression) of ITGB3
6) Confidence 0.52 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.09 Pain Relevance 0
To elucidate potential mechanisms by which Meis1 might control endometrial function and receptivity to the implanting blastocyst, we tested the effect of altering Meis1 expression on Itgb3 expression.
Gene_expression (expression) of Itgb3
7) Confidence 0.52 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
The expression pattern of MEIS1, its contribution to pinopode formation in mouse and its effect on Itgb3 expression suggest that the effects of MEIS1 on endometrial function occur through affecting the affinity and specificity of HOXA10–DNA interactions, leading to the regulation of downstream targets of HOXA10.
Gene_expression (expression) of Itgb3
8) Confidence 0.52 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.17 Pain Relevance 0
To obtain a first indication of differential Itgb3 mRNA expression, peri-implantation uteri from mice treated with pcDNA4/MEIS1 or empty pcDNA4 (as a negative control), or with pTER/Meis1 or non-targeting pTER (as a negative control) were analyzed by RT–PCR.
Gene_expression (expression) of Itgb3
9) Confidence 0.45 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Levels of Itgb3 expression were significantly decreased in endometrium transfected with pTER/Meis1 siRNA compared with the control.
Gene_expression (Levels) of Itgb3 in endometrium
10) Confidence 0.40 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Levels of Itgb3 expression were significantly decreased in endometrium transfected with pTER/Meis1 siRNA compared with the control.
Gene_expression (expression) of Itgb3 in endometrium
11) Confidence 0.40 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Together, these results showed that, in a murine uterine receptivity model, the expression of the known Hoxa10 target Itgb3 could be regulated by the manipulation of Meis1 expression, suggesting Meis1 action through co-operation, or possibly interaction, with Hoxa10.


Gene_expression (expression) of Itgb3 in uterine
12) Confidence 0.40 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
In contrast, Itgb3 expression was lower in mice transfected with Meis1 siRNA expression constructs than in those transfected with the non-targeting siRNA construct.
Gene_expression (expression) of Itgb3
13) Confidence 0.40 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Itgb3 expression levels appeared higher in mice transfected with pcDNA4/MEIS1 expression construct compared with the pcDNA4 control.
Gene_expression (expression) of Itgb3
14) Confidence 0.40 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
-actin (35, 30 or 25 cycles) and mouse itgb3/?
Gene_expression (/) of itgb3
15) Confidence 0.39 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Cellular subsets sorted according to expression of CD24a, CD49f, CD61, Epcam, Sca1, and Thy1 cell surface proteins, or metabolic markers (e.g.
Gene_expression (expression) of CD61
16) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920333 Disease Relevance 0.64 Pain Relevance 0

General Comments

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