INT233219

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2008
Negated 0
Speculated 3
Reported most in Body
Documents 1
Total Number 22
Disease Relevance 1.79
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Meis1) DNA binding (Meis1)
Anatomy Link Frequency
embryo 8
uterus 8
endometrium 4
molar 2
Meis1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 22 84.52 Quite High
anesthesia 22 5.00 Very Low Very Low Very Low
endometriosis 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 44 96.24 Very High Very High Very High
Congenital Anomalies 22 91.40 High High
Anaemia 22 85.68 High High
Leukemia 110 85.20 High High
Hemorrhage 22 84.52 Quite High
Acute Myeloid Leukemia 88 67.80 Quite High
Hypersensitivity 66 63.20 Quite High
Myeloid Leukemia 22 45.28 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 22 21.80 Low Low
Cancer 66 19.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A first indication of decreased Meis1 expression in the uterus was obtained by RT–PCR, and this was confirmed by western blot on Day 3 after transfection.
Negative_regulation (decreased) of Gene_expression (expression) of Meis1 in uterus
1) Confidence 0.58 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Apparently, decreasing Meis1 expression had a negative effect on efficient pinopode maturation.
Negative_regulation (decreasing) of Gene_expression (expression) of Meis1
2) Confidence 0.58 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Increased or decreased Meis1 expression significantly increased or decreased the expression of integrin ?
Negative_regulation (decreased) of Gene_expression (expression) of Meis1
3) Confidence 0.58 Published 2008 Journal Human Reproduction (Oxford, England) Section Abstract Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
We demonstrated that blocking Meis1 expression reduced pinopode numbers and reduced their ability to differentiate into fully mature forms.
Negative_regulation (blocking) of Gene_expression (expression) of Meis1
4) Confidence 0.58 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.12 Pain Relevance 0.03
Blocking Meis1 expression by siRNA before implantation significantly reduced average implantation rates (P = 0.00001).
Negative_regulation (Blocking) of Gene_expression (expression) of Meis1
5) Confidence 0.58 Published 2008 Journal Human Reproduction (Oxford, England) Section Abstract Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
We found that a blockade of Meis1 expression with Meis1 siRNA was associated with a decrease in Itgb3 mRNA.
Negative_regulation (blockade) of Gene_expression (expression) of Meis1
6) Confidence 0.58 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.06 Pain Relevance 0
To assess whether an up-regulation of Meis1 expression during embryo implantation was essential to this process, the expression of maternal Meis1 was down-regulated in a mouse model by transfection in vivo, as described by (Bagot et al., 2000; Hsieh et al., 2002).
Negative_regulation (regulated) of Gene_expression (expression) of Meis1 in embryo
7) Confidence 0.43 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Down-regulation of Meis1 expression affects murine embryo implantation rate
Negative_regulation (regulation) of Gene_expression (expression) of Meis1 in embryo
8) Confidence 0.43 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
To block or over-express maternal Meis1 expression with Meis1 small interfering RNA (siRNA) or over-expression constructs in a mouse model, we used liposome-mediated gene transfection in the murine uterus, to investigate whether maternal Meis1 expression in the endometrium contributes to implantation.
Spec (investigate) Negative_regulation (block) of Gene_expression (expression) of Meis1 in uterus
9) Confidence 0.43 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.38 Pain Relevance 0
To assess whether an up-regulation of Meis1 expression during embryo implantation was essential to this process, the expression of maternal Meis1 was down-regulated in a mouse model by transfection in vivo, as described by (Bagot et al., 2000; Hsieh et al., 2002).
Negative_regulation (down) of Gene_expression (expression) of Meis1 in embryo
10) Confidence 0.43 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
To block or over-express maternal Meis1 expression with Meis1 small interfering RNA (siRNA) or over-expression constructs in a mouse model, we used liposome-mediated gene transfection in the murine uterus, to investigate whether maternal Meis1 expression in the endometrium contributes to implantation.
Spec (investigate) Negative_regulation (block) of Gene_expression (express) of Meis1 in uterus
11) Confidence 0.43 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.38 Pain Relevance 0
Down-regulation of Meis1 expression affects murine embryo implantation rate
Negative_regulation (Down) of Gene_expression (expression) of Meis1 in embryo
12) Confidence 0.43 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
The Meis1 siRNA expression constructs were prepared as follows: oligos T14F 5?
Negative_regulation (prepared) of Gene_expression (expression) of Meis1 siRNA
13) Confidence 0.42 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.10 Pain Relevance 0
Increased or decreased Meis1 expression significantly increased or decreased the expression of integrin ?
Negative_regulation (decreased) of Gene_expression (expression) of Meis1
14) Confidence 0.42 Published 2008 Journal Human Reproduction (Oxford, England) Section Abstract Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
When mouse endometrium was transfected with Meis1 siRNA at the time of implantation, the number of embryos that could implant in the uterus was reduced by 40%.
Negative_regulation (reduced) of Gene_expression (transfected) of Meis1 siRNA in uterus
15) Confidence 0.42 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.17 Pain Relevance 0.04
We found that a blockade of Meis1 expression with Meis1 siRNA was associated with a decrease in Itgb3 mRNA.
Negative_regulation (blockade) of Gene_expression (expression) of Meis1 siRNA
16) Confidence 0.42 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.06 Pain Relevance 0
Levels of Meis1 mRNA and protein (Fig. 4b and c) were significantly decreased in endometrium transfected with pTER/Meis1 siRNA compared with the control.
Negative_regulation (decreased) of Gene_expression (Levels) of Meis1 mRNA in endometrium
17) Confidence 0.42 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.05 Pain Relevance 0
Decreased expression of Meis1 therefore resulted in a significant decrease in litter size (see legend to Fig. 5a).
Negative_regulation (Decreased) of Gene_expression (expression) of Meis1
18) Confidence 0.42 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.09 Pain Relevance 0
The probe for human MEIS1 was a 1:1 molar mixture of single stranded DNA oligonucleotides complementary to the 5?
Negative_regulation (mixture) of Gene_expression (probe) of MEIS1 in molar
19) Confidence 0.42 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.18 Pain Relevance 0
We demonstrated that blocking Meis1 expression reduced pinopode numbers and reduced their ability to differentiate into fully mature forms.
Negative_regulation (blocking) of Gene_expression (expression) of Meis1
20) Confidence 0.42 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.12 Pain Relevance 0.03

General Comments

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