INT233220

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 19
Disease Relevance 1.26
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Meis1) DNA binding (Meis1)
Anatomy Link Frequency
embryo 4
uterine 4
uterus 2
endometrium 2
Meis1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 19 97.44 Very High Very High Very High
cva 19 88.56 High High
endometriosis 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dislocations 19 96.76 Very High Very High Very High
Hyperplasia 19 90.16 High High
Anaemia 19 89.72 High High
Hemorrhage 19 88.56 High High
Cancer 57 86.48 High High
Congenital Anomalies 19 80.28 Quite High
Leukemia 95 70.72 Quite High
Acute Myeloid Leukemia 76 70.16 Quite High
Myeloid Leukemia 19 56.40 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 19 25.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess whether an up-regulation of Meis1 expression during embryo implantation was essential to this process, the expression of maternal Meis1 was down-regulated in a mouse model by transfection in vivo, as described by (Bagot et al., 2000; Hsieh et al., 2002).
Regulation (regulation) of Gene_expression (expression) of Meis1 in embryo
1) Confidence 0.61 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
To assess potential regulation of MEIS1 expression during the reproductive cycle, densitometric analysis was performed on all samples, and the average abundance of MEIS1 during each stage of the menstrual cycle normalized to GAPDH, calculated.
Regulation (regulation) of Gene_expression (expression) of MEIS1
2) Confidence 0.61 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
To elucidate potential mechanisms by which Meis1 might control endometrial function and receptivity to the implanting blastocyst, we tested the effect of altering Meis1 expression on Itgb3 expression.
Regulation (altering) of Gene_expression (expression) of Meis1
3) Confidence 0.61 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Itgb3 mRNA levels significantly increased after up-regulation of Meis1 expression with MEIS1 cDNA.
Regulation (regulation) of Gene_expression (expression) of Meis1
4) Confidence 0.61 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.12 Pain Relevance 0
To support the results of the RT–PCR described above, the effect of Meis1 expression on Itgb3 protein levels was determined by immunohistochemistry on transfected uterine tissue of each group.
Regulation (effect) of Gene_expression (expression) of Meis1 in uterine
5) Confidence 0.61 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
To elucidate potential mechanisms by which Meis1 might control endometrial function and receptivity to the implanting blastocyst, we tested the effect of altering Meis1 expression on Itgb3 expression.
Regulation (effect) of Gene_expression (expression) of Meis1
6) Confidence 0.61 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
In contrast to Meis1 down-regulation, up-regulation of Meis1 expression by pcDNA4/MEIS1 treatment did not significantly alter litter size.


Regulation (regulation) of Gene_expression (expression) of Meis1
7) Confidence 0.61 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
For the experiments studying the effect of MEIS1 expression manipulation on MEIS1 expression, litter size and pinopode formation, the group sizes were five mice each transfected with pcDNA4/MEIS1, empty pcDNA4, pTER/Meis1 siRNA construct or non-targeting pTER, respectively (20 mice in total).
Regulation (effect) of Gene_expression (expression) of MEIS1
8) Confidence 0.45 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.10 Pain Relevance 0.10
To evaluate the effect of up-regulation of Meis1 expression in the adult murine uterus, mice were transfected with the pcDNA4/MEIS1 expression construct, or with empty pcDNA4 plasmid (as a negative control).
Regulation (regulation) of Gene_expression (expression) of Meis1 in uterus
9) Confidence 0.45 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.08 Pain Relevance 0
For the experiments studying the effect of MEIS1 expression manipulation on MEIS1 expression, litter size and pinopode formation, the group sizes were five mice each transfected with pcDNA4/MEIS1, empty pcDNA4, pTER/Meis1 siRNA construct or non-targeting pTER, respectively (20 mice in total).
Regulation (effect) of Gene_expression (expression) of MEIS1
10) Confidence 0.45 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.10 Pain Relevance 0.10
Down-regulation of Meis1 expression affects murine embryo implantation rate
Regulation (regulation) of Gene_expression (expression) of Meis1 in embryo
11) Confidence 0.45 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Itgb3 mRNA levels significantly increased after up-regulation of Meis1 expression with MEIS1 cDNA.
Regulation (regulation) of Gene_expression (expression) of MEIS1
12) Confidence 0.45 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.13 Pain Relevance 0
To assess the importance of maternal Meis1 expression in a mouse model, the uteri of Day 2 pregnant mice were injected with Meis1 over-expression or small interfering RNA (siRNA) constructs.
Regulation (importance) of Gene_expression (expression) of Meis1
13) Confidence 0.45 Published 2008 Journal Human Reproduction (Oxford, England) Section Abstract Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
We conclude from these experiments that manipulation of adult Meis1 expression significantly affected fertility in the mouse.


Regulation (affected) of Gene_expression (expression) of Meis1
14) Confidence 0.45 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.12 Pain Relevance 0
Therefore, to investigate the role of Meis1 in adult reproductive function in a mouse model, we altered the expression of the Meis1 gene in the adult murine endometrium.
Regulation (altered) of Gene_expression (expression) of Meis1 in endometrium
15) Confidence 0.27 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.18 Pain Relevance 0.04
The expression pattern of MEIS1, its contribution to pinopode formation in mouse and its effect on Itgb3 expression suggest that the effects of MEIS1 on endometrial function occur through affecting the affinity and specificity of HOXA10–DNA interactions, leading to the regulation of downstream targets of HOXA10.
Regulation (effect) of Gene_expression (expression) of MEIS1
16) Confidence 0.27 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.18 Pain Relevance 0
To investigate a possible connection between Meis1 and Hoxa10 function in murine uterine development and embryonic implantation, we evaluated the effect of Meis1 expression manipulation on Itgb3 expression.
Regulation (effect) of Gene_expression (expression) of Meis1 in uterine
17) Confidence 0.27 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
In this study, we examined whether the expression of pinopodes could be also affected by altering Meis1 expression levels.
Regulation (affected) of Gene_expression (expression) of Meis1
18) Confidence 0.27 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.13 Pain Relevance 0.03
In this study, we examined whether the expression of pinopodes could be also affected by altering Meis1 expression levels.
Regulation (altering) of Gene_expression (expression) of Meis1
19) Confidence 0.27 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.13 Pain Relevance 0.03

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