INT233233

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.97
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Meis1) DNA binding (Meis1)
Anatomy Link Frequency
endometrium 2
Meis1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 7 85.28 High High
cva 7 72.16 Quite High
endometriosis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Myeloid Leukemia 28 99.12 Very High Very High Very High
Myeloid Leukemia 7 92.24 High High
Dislocations 7 84.60 Quite High
Hemorrhage 7 72.16 Quite High
Hyperplasia 7 71.16 Quite High
Anaemia 7 69.52 Quite High
Congenital Anomalies 7 67.68 Quite High
Cancer 21 67.48 Quite High
Leukemia 35 63.60 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 59.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MEIS1 mRNA levels appeared significantly increased in the mid secretory phase, closely resembling the expression pattern of HOXA10.
Spec (appeared) Positive_regulation (increased) of MEIS1 mRNA
1) Confidence 0.69 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.18 Pain Relevance 0.03
The identification of MEIS1 as a potential HOXA10 co-operating gene could lead to elucidation of a partial HOXA10 network in endometrial development, but could also establish MEIS1 in a signaling network in its own right.


Positive_regulation (establish) of MEIS1
2) Confidence 0.69 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.14 Pain Relevance 0
The co-activation of HOXA9 and MEIS1 is a common event in AML (Lawrence et al., 1999; Camós et al., 2006), but co-regulation of MEIS1 and HOXA9, and also of HOXA10, might play a role in pathogenesis of acute lymphocytic and acute myeloid leukemias associated with ALL-1 fusions (Rozovskaia et al., 2001; Ferrando et al., 2003; Dik et al., 2005).
Positive_regulation (activation) of MEIS1 associated with myeloid leukemia and acute myeloid leukemia
3) Confidence 0.69 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.25 Pain Relevance 0
Levels of Meis1 mRNA and protein were significantly increased in endometrium transfected with the pcDNA4/MEIS1 expression construct compared with the control (Fig. 4c and d).
Positive_regulation (increased) of Meis1 mRNA in endometrium
4) Confidence 0.69 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.07 Pain Relevance 0
For the experiments studying the effect of MEIS1 expression manipulation on Itgb3 expression, 25 mice each were transfected with pcDNA4/MEIS1, empty pcDNA4, pTER/Meis1 siRNA construct or non-targeting pTER, respectively (100 mice in total).
Positive_regulation (manipulation) of MEIS1
5) Confidence 0.50 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.08 Pain Relevance 0.09
This observation pointed to the possibility that MEIS1 is an active cofactor of HOXA10 in the human endometrium.
Positive_regulation (active) of MEIS1 in endometrium
6) Confidence 0.50 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.19 Pain Relevance 0.04
The constructs were verified by sequencing and siRNA-mediated MEIS1 protein and mRNA knockdown by both constructs was demonstrated (Revet et al., manuscript in preparation, see also Fig. 2 in Geerts et al., 2005).
Positive_regulation (mediated) of MEIS1 protein
7) Confidence 0.46 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.06 Pain Relevance 0

General Comments

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