INT233237

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2008
Negated 0
Speculated 7
Reported most in Body
Documents 1
Total Number 105
Disease Relevance 9.69
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Meis1) DNA binding (Meis1)
Anatomy Link Frequency
endometrium 22
uterus 11
uterine 6
embryo 3
female reproductive tract 2
Meis1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 105 97.04 Very High Very High Very High
cva 105 88.08 High High
endometriosis 105 10.76 Low Low
Disease Link Frequency Relevance Heat
Leukemia 525 99.86 Very High Very High Very High
Acute Myeloid Leukemia 420 99.66 Very High Very High Very High
Dislocations 105 96.36 Very High Very High Very High
Neuroblastoma 210 96.24 Very High Very High Very High
Congenital Anomalies 105 95.36 Very High Very High Very High
Cancer 315 94.24 High High
Hyperplasia 105 90.16 High High
Anaemia 105 89.24 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 105 88.32 High High
Hemorrhage 105 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A first indication of decreased Meis1 expression in the uterus was obtained by RT–PCR, and this was confirmed by western blot on Day 3 after transfection.
Gene_expression (expression) of Meis1 in uterus
1) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
To investigate the site of MEIS1 expression in the human endometrium, and as a support of the MEIS1 expression detected with RT–PCR described above, in situ hybridization was performed.
Gene_expression (expression) of MEIS1 in endometrium
2) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Down-regulation of Meis1 expression affects murine embryo implantation rate
Gene_expression (expression) of Meis1 in embryo
3) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
MEIS1 expression has been previously demonstrated in epithelial cells of the developing female reproductive tract (Dintilhac et al., 2005).
Gene_expression (expression) of MEIS1 in epithelial cells
4) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
In contrast, supernumerary pinopodes could be induced by over-expression of Meis1.
Gene_expression (over) of Meis1
5) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.11 Pain Relevance 0.03
MEIS1 mRNA is expressed in the human endometrial stroma and glands
Gene_expression (expressed) of MEIS1 mRNA in glands
6) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Finally, the MEIS3 gene showed overall much lower expression (5–7-fold) than the MEIS1 and MEIS2 genes.
Gene_expression (expression) of MEIS1
7) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Itgb3 mRNA levels significantly increased after up-regulation of Meis1 expression with MEIS1 cDNA.
Gene_expression (expression) of MEIS1
8) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.13 Pain Relevance 0
This significant reduction in implantation sites demonstrated that, in normal embryonic development, optimal implantation benefits from maternal Meis1 expression.
Gene_expression (expression) of Meis1
9) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.15 Pain Relevance 0.04
These results were a first indication that MEIS1 expression varied during the menstrual cycle, markedly increasing at the mid secretory phase (S2), which corresponded to the time of implantation.


Gene_expression (expression) of MEIS1
10) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
To block or over-express maternal Meis1 expression with Meis1 small interfering RNA (siRNA) or over-expression constructs in a mouse model, we used liposome-mediated gene transfection in the murine uterus, to investigate whether maternal Meis1 expression in the endometrium contributes to implantation.
Gene_expression (expression) of Meis1 in uterus
11) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.38 Pain Relevance 0
The staining of 100 consecutive cells in five non-adjacent microscopic fields was evaluated to quantify the expression of MEIS1.


Gene_expression (expression) of MEIS1
12) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.19 Pain Relevance 0
To support the results of the RT–PCR described above, the effect of Meis1 expression on Itgb3 protein levels was determined by immunohistochemistry on transfected uterine tissue of each group.
Gene_expression (expression) of Meis1 in uterine
13) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Increased or decreased Meis1 expression significantly increased or decreased the expression of integrin ?
Gene_expression (expression) of Meis1
14) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Abstract Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
To evaluate the effect of up-regulation of Meis1 expression in the adult murine uterus, mice were transfected with the pcDNA4/MEIS1 expression construct, or with empty pcDNA4 plasmid (as a negative control).
Gene_expression (expression) of Meis1 in uterus
15) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.08 Pain Relevance 0
To block or over-express maternal Meis1 expression with Meis1 small interfering RNA (siRNA) or over-expression constructs in a mouse model, we used liposome-mediated gene transfection in the murine uterus, to investigate whether maternal Meis1 expression in the endometrium contributes to implantation.
Gene_expression (express) of Meis1 in uterus
16) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.38 Pain Relevance 0
In conclusion, this study shows for the first time that MEIS1 expression contributes to endometrial receptivity in mouse.
Gene_expression (expression) of MEIS1
17) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.30 Pain Relevance 0
In this study, we examined whether the expression of pinopodes could be also affected by altering Meis1 expression levels.
Gene_expression (expression) of Meis1
18) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.13 Pain Relevance 0.03
To assess whether an up-regulation of Meis1 expression during embryo implantation was essential to this process, the expression of maternal Meis1 was down-regulated in a mouse model by transfection in vivo, as described by (Bagot et al., 2000; Hsieh et al., 2002).
Gene_expression (expression) of Meis1 in embryo
19) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Levels of Meis1 mRNA and protein were significantly increased in endometrium transfected with the pcDNA4/MEIS1 expression construct compared with the control (Fig. 4c and d).
Gene_expression (expression) of MEIS1 in endometrium
20) Confidence 0.77 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.06 Pain Relevance 0

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