INT233241

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0.48
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Meis1) DNA binding (Meis1)
Anatomy Link Frequency
embryo 1
uterine 1
Meis1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 9 64.04 Quite High
anesthesia 9 5.00 Very Low Very Low Very Low
endometriosis 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Myeloid Leukemia 36 98.94 Very High Very High Very High
Myeloid Leukemia 9 96.12 Very High Very High Very High
Congenital Anomalies 9 85.00 Quite High
Leukemia 45 71.36 Quite High
Anaemia 9 65.20 Quite High
Hemorrhage 9 64.04 Quite High
Cancer 27 5.00 Very Low Very Low Very Low
Hypersensitivity 27 5.00 Very Low Very Low Very Low
Neuroblastoma 18 5.00 Very Low Very Low Very Low
Hyperplasia 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The co-activation of HOXA9 and MEIS1 is a common event in AML (Lawrence et al., 1999; Camós et al., 2006), but co-regulation of MEIS1 and HOXA9, and also of HOXA10, might play a role in pathogenesis of acute lymphocytic and acute myeloid leukemias associated with ALL-1 fusions (Rozovskaia et al., 2001; Ferrando et al., 2003; Dik et al., 2005).
Regulation (regulation) of MEIS1 associated with myeloid leukemia and acute myeloid leukemia
1) Confidence 0.61 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.27 Pain Relevance 0
We concluded that the naturally occurring up-regulation of Meis1 in the reproductive cycle contributes to normal embryo implantation.
Regulation (regulation) of Meis1 in embryo
2) Confidence 0.45 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.09 Pain Relevance 0
To investigate a possible connection between Meis1 and Hoxa10 function in murine uterine development and embryonic implantation, we evaluated the effect of Meis1 expression manipulation on Itgb3 expression.
Regulation (manipulation) of Meis1 in uterine
3) Confidence 0.45 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Effect of Meis1 on murine pinopode formation
Regulation (Effect) of Meis1
4) Confidence 0.39 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
In this study, we examined whether the expression of pinopodes could be also affected by altering Meis1 expression levels.
Regulation (altering) of Meis1
5) Confidence 0.27 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.13 Pain Relevance 0.03
Human MEIS1 or mouse Meis1 and Itgb3 mRNA levels were calculated as a ratio of the densitometric values for MEIS1, Meis1, or Itgb3 to their corresponding GAPDH or ?
Regulation (values) of Meis1
6) Confidence 0.27 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Human MEIS1 or mouse Meis1 and Itgb3 mRNA levels were calculated as a ratio of the densitometric values for MEIS1, Meis1, or Itgb3 to their corresponding GAPDH or ?
Regulation (values) of MEIS1
7) Confidence 0.27 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
All numerical results are expressed as the mean value ± SD, except for the Affymetrix expression values of MEIS1–3 mRNAs in normal human tissue, which are represented as mean value ± SEM.
Neg (except) Regulation (values) of MEIS1
8) Confidence 0.27 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Human MEIS1 or mouse Meis1 and Itgb3 mRNA levels were calculated as a ratio of the densitometric values for MEIS1, Meis1, or Itgb3 to their corresponding GAPDH or ?
Regulation (values) of Meis1
9) Confidence 0.12 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0

General Comments

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