INT233248

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 19
Disease Relevance 1.31
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Meis1) DNA binding (Meis1)
Anatomy Link Frequency
endometrium 8
uterus 6
uterine 2
Meis1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 19 92.12 High High
cva 19 84.52 Quite High
endometriosis 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 19 95.36 Very High Very High Very High
Cancer 57 95.20 Very High Very High Very High
Dislocations 19 91.44 High High
Hyperplasia 19 89.12 High High
Anaemia 19 85.68 High High
Hemorrhage 19 84.52 Quite High
Leukemia 95 70.96 Quite High
Acute Myeloid Leukemia 76 69.28 Quite High
Myeloid Leukemia 19 55.52 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 19 21.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MEIS1 expression was confirmed during the human menstrual cycle by RT–PCR and in situ hybridization and was increased during the secretory compared with proliferative phase of the cycle (P = 0.0001), the time of implantation.
Positive_regulation (increased) of Gene_expression (expression) of MEIS1
1) Confidence 0.69 Published 2008 Journal Human Reproduction (Oxford, England) Section Abstract Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
These results were a first indication that MEIS1 expression varied during the menstrual cycle, markedly increasing at the mid secretory phase (S2), which corresponded to the time of implantation.


Positive_regulation (increasing) of Gene_expression (expression) of MEIS1
2) Confidence 0.69 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Increased or decreased Meis1 expression significantly increased or decreased the expression of integrin ?
Positive_regulation (Increased) of Gene_expression (expression) of Meis1
3) Confidence 0.69 Published 2008 Journal Human Reproduction (Oxford, England) Section Abstract Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
A first indication of increased Meis1 expression in the uterus was obtained by RT–PCR and this was confirmed by western blot.
Positive_regulation (increased) of Gene_expression (expression) of Meis1 in uterus
4) Confidence 0.69 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.07 Pain Relevance 0
Levels of Meis1 mRNA and protein (Fig. 4b and c) were significantly decreased in endometrium transfected with pTER/Meis1 siRNA compared with the control.
Positive_regulation (transfected) of Gene_expression (transfected) of Meis1 siRNA in endometrium
5) Confidence 0.50 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.05 Pain Relevance 0
As described above, no uterine histological changes could be detected at the light microscopy level in mice transfected with Meis1 DNA constructs.
Positive_regulation (transfected) of Gene_expression (transfected) of Meis1 in uterine
6) Confidence 0.50 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
We conclude from these experiments that manipulation of adult Meis1 expression significantly affected fertility in the mouse.


Positive_regulation (adult) of Gene_expression (expression) of Meis1
7) Confidence 0.50 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.12 Pain Relevance 0
***Fig. 6a and b shows a typical section of endometrium from a pcDNA4/MEIS1-treated mouse, and an empty pcDNA4-treated control mouse; there was a significant increase in the development of pinopodes in the mouse transfected with MEIS1 over-expression plasmid.
Positive_regulation (transfected) of Gene_expression (transfected) of MEIS1 in endometrium
8) Confidence 0.50 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Pups of mice transfected with Meis1 siRNA were born following a normal length gestation of 18–22 days, were of normal size and demonstrated no morphological abnormalities.
Positive_regulation (transfected) of Gene_expression (transfected) of Meis1 siRNA associated with congenital anomalies
9) Confidence 0.50 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.10 Pain Relevance 0
Increased or decreased Meis1 expression significantly increased or decreased the expression of integrin ?
Positive_regulation (increased) of Gene_expression (expression) of Meis1
10) Confidence 0.50 Published 2008 Journal Human Reproduction (Oxford, England) Section Abstract Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
When mouse endometrium was transfected with Meis1 siRNA at the time of implantation, the number of embryos that could implant in the uterus was reduced by 40%.
Positive_regulation (transfected) of Gene_expression (transfected) of Meis1 siRNA in uterus
11) Confidence 0.50 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.17 Pain Relevance 0.04
Levels of Itgb3 mRNA appeared significantly decreased in endometrium transfected with pTER/Meis1 siRNA compared with the control.
Positive_regulation (transfected) of Gene_expression (transfected) of Meis1 siRNA in endometrium
12) Confidence 0.50 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
In contrast, supernumerary pinopodes could be induced by over-expression of Meis1.
Positive_regulation (induced) of Gene_expression (over) of Meis1
13) Confidence 0.50 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.11 Pain Relevance 0.03
For the experiments studying the effect of MEIS1 expression manipulation on MEIS1 expression, litter size and pinopode formation, the group sizes were five mice each transfected with pcDNA4/MEIS1, empty pcDNA4, pTER/Meis1 siRNA construct or non-targeting pTER, respectively (20 mice in total).
Positive_regulation (transfected) of Gene_expression (transfected) of MEIS1
14) Confidence 0.50 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.09 Pain Relevance 0.09
Absence of a normal amount of functioning pinopods in mice transfected with Meis1 siRNA could be a mechanism contributing to a less efficient embryonic implantation rate and diminished litter size in these animals.


Positive_regulation (transfected) of Gene_expression (transfected) of Meis1 siRNA
15) Confidence 0.50 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
However, the average number of implantation sites per uterus was 12.2 ± 1.5 in the mice transfected with the control pTER plasmid and 7.6 ± 2.7 in the mice transfected with a pTER/Meis1 siRNA construct (Fig. 5a).
Positive_regulation (transfected) of Gene_expression (transfected) of Meis1 siRNA in uterus
16) Confidence 0.50 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.09 Pain Relevance 0
Itgb3 mRNA levels significantly increased after up-regulation of Meis1 expression with MEIS1 cDNA.
Positive_regulation (up) of Gene_expression (expression) of Meis1
17) Confidence 0.46 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.12 Pain Relevance 0
In conclusion, this study shows for the first time that MEIS1 expression contributes to endometrial receptivity in mouse.
Positive_regulation (contributes) of Gene_expression (expression) of MEIS1
18) Confidence 0.46 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.30 Pain Relevance 0
Levels of Meis1 mRNA and protein were significantly increased in endometrium transfected with the pcDNA4/MEIS1 expression construct compared with the control (Fig. 4c and d).
Positive_regulation (increased) of Gene_expression (Levels) of Meis1 mRNA in endometrium
19) Confidence 0.46 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.07 Pain Relevance 0

General Comments

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