INT233250

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.34
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hoxa10) DNA binding (Hoxa10)
Anatomy Link Frequency
endometrium 1
Hoxa10 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
endometriosis 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 10 74.40 Quite High
Cancer 6 72.80 Quite High
Hyperplasia 2 66.72 Quite High
Myeloid Leukemia 2 64.32 Quite High
Acute Myeloid Leukemia 8 56.88 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 34.72 Quite Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Neuroblastoma 4 5.00 Very Low Very Low Very Low
Anaemia 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ablation of the PBX cofactor half-site results in a loss of HOXA10–PBX2 binding to the EMX2 probe, suggesting the importance of the PBX2/HOXA10 protein–protein interaction in endometrium for high affinity HOXA10 binding to its target genes (Sarno et al., 2005).
Negative_regulation (loss) of HOXA10 in endometrium
1) Confidence 0.30 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.34 Pain Relevance 0
Hoxa10 null-mutant mice or mice in which Hoxa10 has been blocked using antisense oligonucleotides demonstrate decreased litter size due to failure of implantation (Benson et al., 1996; Bagot et al., 2000).
Negative_regulation (blocked) of Hoxa10
2) Confidence 0.26 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0

General Comments

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