INT233260

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 37
Total Number 39
Disease Relevance 3.45
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HOXA9) cytoplasm (HOXA9)
Anatomy Link Frequency
myeloid cells 2
stem cell 2
precursor cells 1
endometrium 1
hematopoietic cell 1
HOXA9 (Homo sapiens)
HOXA9 - N51S (6)
Pain Link Frequency Relevance Heat
cytokine 73 91.00 High High
cINOD 105 5.00 Very Low Very Low Very Low
aspirin 79 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 285 99.78 Very High Very High Very High
Cytomegalovirus Infection 105 99.70 Very High Very High Very High
Myeloid Leukemia 211 99.12 Very High Very High Very High
Coronary Artery Disease 198 96.40 Very High Very High Very High
Cancer 254 90.40 High High
Acute Myeloid Leukemia 4 87.36 High High
Apoptosis 15 59.56 Quite High
Chronic Lymphoid Leukemia 70 6.76 Low Low
Hematologic Neoplasms 70 5.20 Low Low
Lymphatic System Cancer 70 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, NUP98-HOXA9 modulates the expression of a larger set of genes than HOXA9 in a myeloid cell line [6].
Gene_expression (expression) of HOXA9 in myeloid cell
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0.23 Pain Relevance 0
Primary human CD34+ cells were transduced with retroviral vectors expressing NUP98-HOXA9, NUP98-HOXA9/N51S, wild-type HOXA9, and HOXA9?
Gene_expression (expressing) of HOXA9 (N51S)
2) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
For example, HOXA9 expression clearly decreased the numbers of mature myeloid cells and increased the numbers of less mature myeloid cells as judged by morphologic examination of Giemsa-stained Cytospin smears (Fig. 8 and Table 1).
Gene_expression (expression) of HOXA9 in myeloid cells
3) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0.06 Pain Relevance 0
In contrast, cells expressing either HOXA9 or HOXA9?
Gene_expression (expressing) of HOXA9
4) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
To determine the relative contributions of the NUP98 and HOXA9 moieties to disruption of hematopoietic differentiation of primary human CD34+ cells by NUP98-HOXA9, retroviral vectors were prepared that express NUP98-HOXA9, wild-type HOXA9, NUP98-HOXA9/N51S, and a mutant of NUP98-HOXA9 that lacks the NUP98 moiety (HOXA9?
Gene_expression (express) of HOXA9
5) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
The different samples showed similar growth profiles for approximately the first month, after which the numbers of control cells and cells expressing HOXA9?
Gene_expression (expressing) of HOXA9
6) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0.05
Primary human CD34+ cells were transduced with retroviral vectors expressing NUP98-HOXA9, NUP98-HOXA9/N51S, wild-type HOXA9, and HOXA9?
Gene_expression (expressing) of HOXA9
7) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
In contrast, cells expressing either HOXA9 or HOXA9?
Gene_expression (expressing) of HOXA9
8) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
Primary human CD34+ cells were transduced with retroviral vectors expressing NUP98-HOXA9, NUP98-HOXA9/N51S, wild-type HOXA9, and HOXA9?
Gene_expression (expressing) of HOXA9
9) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
While wild-type HOXA9 is overexpressed in a subset of human AML [58], [59], [60], [61], its effects on primary human hematopoietic cell differentiation and proliferation have not been previously reported, and its contribution to human myeloid leukemogenesis is not clear.
Gene_expression (overexpressed) of HOXA9 in hematopoietic cell associated with myeloid leukemia
10) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0.10 Pain Relevance 0
To determine the relative contributions of the NUP98 and HOXA9 moieties to disruption of hematopoietic differentiation of primary human CD34+ cells by NUP98-HOXA9, retroviral vectors were prepared that express NUP98-HOXA9, wild-type HOXA9, NUP98-HOXA9/N51S, and a mutant of NUP98-HOXA9 that lacks the NUP98 moiety (HOXA9?
Gene_expression (express) of HOXA9 (N51S)
11) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
Primary human CD34+ cells were transduced with retroviral vectors expressing NUP98-HOXA9, NUP98-HOXA9/N51S, wild-type HOXA9, and HOXA9?
Gene_expression (expressing) of HOXA9
12) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
Though co-expression and interaction of MEIS1 with Abd-B-like HOX transcription factors was convincingly demonstrated in leukemia, the data on MEIS1 gene expression and function in the endometrium were still scarce.
Gene_expression (expression) of Abd-B in endometrium associated with leukemia
13) Confidence 0.65 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.49 Pain Relevance 0
The two moieties of NUP98-HOXA9 act synergistically to induce proliferation of primary human CD34+ cells
Gene_expression (act) of HOXA9
14) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0.03
Cells expressing HOXA9 or NUP98-HOXA9/N51S showed a modest degree of growth for another few weeks before beginning to decline as well.
Gene_expression (expressing) of HOXA9
15) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0.04
Some of these genes are also dysregulated by HOXA9 and/or HOXA9?
Gene_expression (/) of HOXA9
16) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
K562 (107) cells were nucleofected using a Nucleofector device (Lonza, Cologne, Germany) with either empty pTracer-CMV/Bsd vector or vector containing Flag-tagged NUP98-HOXA9 or NUP98-HOXA9/N51S and collected after 12 h.
Gene_expression (tagged) of HOXA9 associated with cytomegalovirus infection
17) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0.17 Pain Relevance 0
To determine the relative contributions of the NUP98 and HOXA9 moieties to disruption of hematopoietic differentiation of primary human CD34+ cells by NUP98-HOXA9, retroviral vectors were prepared that express NUP98-HOXA9, wild-type HOXA9, NUP98-HOXA9/N51S, and a mutant of NUP98-HOXA9 that lacks the NUP98 moiety (HOXA9?
Gene_expression (express) of HOXA9
18) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
To determine the relative contributions of the NUP98 and HOXA9 moieties to disruption of hematopoietic differentiation of primary human CD34+ cells by NUP98-HOXA9, retroviral vectors were prepared that express NUP98-HOXA9, wild-type HOXA9, NUP98-HOXA9/N51S, and a mutant of NUP98-HOXA9 that lacks the NUP98 moiety (HOXA9?
Gene_expression (express) of HOXA9
19) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
In order to assess the relative contributions of the NUP98 and HOXA9 moieties to this proliferative effect, NUP98-HOXA9, NUP98-HOXA9/N51S, wild-type HOXA9, and HOXA9?
Gene_expression (moieties) of HOXA9
20) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0.04

General Comments

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