INT233269

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hoxa10, Meis1) DNA binding (Hoxa10, Meis1)
Anatomy Link Frequency
uterine 1
Hoxa10 (Mus musculus)
Meis1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 3 22.72 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
endometriosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 15 99.16 Very High Very High Very High
Myeloid Leukemia 3 89.08 High High
Acute Myeloid Leukemia 12 82.40 Quite High
Cancer 9 24.24 Low Low
Anaemia 3 23.88 Low Low
Hemorrhage 3 22.72 Low Low
Hyperplasia 3 18.16 Low Low
Hypersensitivity 9 5.00 Very Low Very Low Very Low
Neuroblastoma 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, binding of MEIS1 to HOXA10 could be demonstrated in vitro (Williams et al., 2005).
HOXA10 Binding (binding) of MEIS1
1) Confidence 0.38 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.27 Pain Relevance 0
It appeared likely that Itgb3 was not regulated by Hoxa10 monomer, but by a heterodimeric or heterotrimeric transcription complex containing Meis1.
Hoxa10 monomer Binding (heterodimeric) of Meis1
2) Confidence 0.30 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.15 Pain Relevance 0
Together, these results showed that, in a murine uterine receptivity model, the expression of the known Hoxa10 target Itgb3 could be regulated by the manipulation of Meis1 expression, suggesting Meis1 action through co-operation, or possibly interaction, with Hoxa10.


Hoxa10 Binding (interaction) of Meis1 in uterine
3) Confidence 0.28 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0

General Comments

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