INT233294

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 4.07
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Mgmt) nucleus (Mgmt) DNA binding (Mgmt)
Mgmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
palliative 12 77.92 Quite High
imagery 17 74.28 Quite High
vincristine 7 63.16 Quite High
cva 15 5.00 Very Low Very Low Very Low
anticonvulsant 9 5.00 Very Low Very Low Very Low
Bioavailability 9 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Antiemetics 7 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 281 99.98 Very High Very High Very High
Toxicity 87 97.72 Very High Very High Very High
Disease 144 97.00 Very High Very High Very High
Recurrence 84 96.68 Very High Very High Very High
Glioma 272 93.28 High High
Death 36 93.00 High High
Apoptosis 12 81.08 Quite High
Vomiting 59 78.32 Quite High
Fatigue 24 76.88 Quite High
Disease Progression 28 61.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Correlation of methylation status of the MGMT gene promoter region with survival revealed that patients with tumors containing methylated MGMT promoter had a far better prognosis than those with only unmethylated promoter as measured by median survival (18.2 months vs 12.2 months).
Positive_regulation (methylated) of MGMT promoter associated with cancer
1) Confidence 0.49 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387286 Disease Relevance 0.38 Pain Relevance 0
For example, patients with tumors harboring methylated MGMT promoter were found to have better outcomes compared with those with tumors that had unmethylated MGMT promoters.99 The benefit of TMZ for the elderly (age >70 years) is unknown.28
Positive_regulation (harboring) of MGMT associated with cancer
2) Confidence 0.09 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.49 Pain Relevance 0.03
Patients with tumors that had methylated MGMT promoter had a statistically significantly longer follow-up period before disease recurrence compared with patients with tumors that had unmethylated MGMT promoter (19.6 ± 17.7 versus 2.3 ± 1.7 months; P = 0.049).
Positive_regulation (methylated) of MGMT associated with cancer, disease and recurrence
3) Confidence 0.09 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.92 Pain Relevance 0.12
Patients with silenced MGMT gene expression due to hypermethylation of MGMT promoters were shown to respond more favorably to concurrent TMZ/RT compared with those who had unmethylated MGMT promoters and high MGMT gene expression levels.99 In this study, tumor samples obtained from nGBM patients enrolled in the EORTC/NCIC phase III study were analyzed for MGMT promoter methylation status by methylation-specific polymerase chain reaction techniques99 (Table 8).


Positive_regulation (unmethylated) of MGMT associated with cancer
4) Confidence 0.09 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.47 Pain Relevance 0
Conversely, a deficient MMR system coupled with high MGMT expression levels may mediate TMZ resistance.44,45

TMZ toxicity profile

Positive_regulation (high) of MGMT associated with toxicity
5) Confidence 0.09 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.84 Pain Relevance 0
For example, patients with tumors harboring methylated MGMT promoter were found to have better outcomes compared with those with tumors that had unmethylated MGMT promoters.99 The benefit of TMZ for the elderly (age >70 years) is unknown.28
Positive_regulation (unmethylated) of MGMT associated with cancer
6) Confidence 0.09 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.49 Pain Relevance 0.03
For example, patients with tumors harboring methylated MGMT promoter were found to have better outcomes compared with those with tumors that had unmethylated MGMT promoters.99 The benefit of TMZ for the elderly (age >70 years) is unknown.28
Positive_regulation (methylated) of MGMT associated with cancer
7) Confidence 0.09 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.49 Pain Relevance 0.03

General Comments

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