INT23330

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Context Info
Confidence 0.48
First Reported 1981
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 79
Total Number 81
Disease Relevance 10.06
Pain Relevance 35.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna7) plasma membrane (Chrna7) cytoplasm (Chrna7)
Anatomy Link Frequency
brain 4
cortex 3
cerebral cortex 2
lateral 2
muscle 1
Chrna7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Piles 69 100.00 Very High Very High Very High
Pain 55 100.00 Very High Very High Very High
local anesthetic 177 99.84 Very High Very High Very High
antagonist 35 99.84 Very High Very High Very High
lidocaine 33 99.84 Very High Very High Very High
sodium channel 195 99.76 Very High Very High Very High
tetrodotoxin 115 99.60 Very High Very High Very High
cerebral cortex 25 99.52 Very High Very High Very High
Potency 38 99.38 Very High Very High Very High
noradrenaline 8 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anorectal Disorders 75 100.00 Very High Very High Very High
Overactive Bladder 18 100.00 Very High Very High Very High
Cervical Cancer 13 100.00 Very High Very High Very High
Neck Pain 1 100.00 Very High Very High Very High
Muscular Atrophy 3 99.62 Very High Very High Very High
Recurrence 36 99.20 Very High Very High Very High
Muscular Spasm 14 98.92 Very High Very High Very High
Disease 76 98.84 Very High Very High Very High
Pain 54 98.64 Very High Very High Very High
Headache 7 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data support the conclusion that BTX-B interacts with a recognition site associated with voltage sensitive sodium channels which is identical to the recognition site for BTX.
BTX Binding (interacts) of associated with sodium channel
1) Confidence 0.48 Published 1981 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 6286124 Disease Relevance 0 Pain Relevance 0.26
The following problems are considered: allosteric interaction of the BTX receptor with structural entities of the sodium channel responsible for its activation, inactivation, ion selectivity, binding of polypeptide (scorpion and anemone) toxins, local anesthetics and many blocking drugs; relationship between BTX-induced changes in the sodium conductance and intramembrane charge movement; relationship between ion selectivity and effective pK of the selectivity filter acid group of sodium channels modified by BTX or aconitine; effects of BTX on the behaviour and conductance (gamma) of single sodium channels.
BTX Binding (interaction) of associated with sodium channel and local anesthetic
2) Confidence 0.47 Published 1985 Journal Neirofiziologiia Section Abstract Doc Link 2410800 Disease Relevance 0 Pain Relevance 0.33
Each of the various BTX molecules interacts with a specific part of SNARE.
BTX Binding (interacts) of
3) Confidence 0.40 Published 2008 Journal Journal of Cutaneous and Aesthetic Surgery Section Body Doc Link PMC2840887 Disease Relevance 0.06 Pain Relevance 0.11
Computer-assisted data analysis allowed two binding sites for BTX-B to be distinguished.
BTX-B Binding (binding) of
4) Confidence 0.39 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2450762 Disease Relevance 0 Pain Relevance 0.38
Brevetoxins and alpha-scorpion toxins cause further allosteric enhancement of BTX-B binding.
BTX-B Binding (binding) of
5) Confidence 0.31 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8394327 Disease Relevance 0 Pain Relevance 0.24
A specific, saturable component of equilibrium binding of [3H]BTX-B to mouse cerebral cortex homogenates was measured, described by an equilibrium dissociation constant of 0.7 microM and a maximum number of binding sites of 90 pmol per gram of tissue (wet weight).
BTX Binding (binding) of in cerebral cortex associated with cerebral cortex
6) Confidence 0.31 Published 1981 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 6286124 Disease Relevance 0 Pain Relevance 0.24
Here we show that [3H]batrachotoxinin-A-ortho-azidobenzoate ([3H]BTX-OAB), a photolabile derivative of BTX, binds covalently upon irradiation to the BTX sodium channel site of rat cerebral cortical synaptoneurosomes.
BTX-OAB Binding (binds) of associated with sodium channel and overactive bladder
7) Confidence 0.31 Published 1993 Journal Toxicon Section Abstract Doc Link 8266344 Disease Relevance 0.36 Pain Relevance 0.21
Another ligand specific for the BTX sodium channel receptor, batrachotoxinin-A 20-alpha-benzoate (BTX-B), competitively inhibited the specific binding of [3H]BTX-OAB.
BTX-OAB Binding (binding) of associated with sodium channel and overactive bladder
8) Confidence 0.31 Published 1993 Journal Toxicon Section Abstract Doc Link 8266344 Disease Relevance 0.50 Pain Relevance 0.35
Here we show that [3H]batrachotoxinin-A-ortho-azidobenzoate ([3H]BTX-OAB), a photolabile derivative of BTX, binds covalently upon irradiation to the BTX sodium channel site of rat cerebral cortical synaptoneurosomes.
BTX Binding (binds) of associated with sodium channel and overactive bladder
9) Confidence 0.31 Published 1993 Journal Toxicon Section Abstract Doc Link 8266344 Disease Relevance 0.36 Pain Relevance 0.21
Repetitive depolarizations greatly facilitated the binding of BTX with NaIIA channels while the membrane was held at -100 mV.
BTX Binding (binding) of
10) Confidence 0.30 Published 1994 Journal Pflugers Arch. Section Abstract Doc Link 8072851 Disease Relevance 0 Pain Relevance 0.30
The estimated association rate constant for BTX binding with the open form of NaIIA channel was 1.11 x 10(6) mol-1.s-1 at room temperature.
BTX Binding (binding) of
11) Confidence 0.30 Published 1994 Journal Pflugers Arch. Section Abstract Doc Link 8072851 Disease Relevance 0 Pain Relevance 0.59
In chloramine-T-pretreated cells, the association rate of BTX binding with the NaIIA channel was 6.5-fold faster than that in untreated cells.
BTX Binding (binding) of
12) Confidence 0.30 Published 1994 Journal Pflugers Arch. Section Abstract Doc Link 8072851 Disease Relevance 0 Pain Relevance 0.40
Their conclusion was that BTX is as effective as GTN for the management of chronic anal fissures, but that it is associated with a lower complication rate.
BTX Binding (associated) of in fissures associated with piles
13) Confidence 0.30 Published 2008 Journal Journal of Cutaneous and Aesthetic Surgery Section Body Doc Link PMC2840903 Disease Relevance 0.67 Pain Relevance 0.39
The role of fissurectomy in conjuction with BTX needs further investigation.[47] Using this algorithm, lateral sphincterotomy can be avoided in most cases and BTX can also be used in patients with a relapse after surgical sphincterotomy.
BTX Binding (used) of in lateral associated with recurrence
14) Confidence 0.30 Published 2008 Journal Journal of Cutaneous and Aesthetic Surgery Section Body Doc Link PMC2840903 Disease Relevance 0.56 Pain Relevance 0.39
The treatment goal for BTX is the interruption of the internal sphincter spasm and thereby, the ischemic state.
BTX Binding (interruption) of in internal associated with muscular spasm
15) Confidence 0.30 Published 2008 Journal Journal of Cutaneous and Aesthetic Surgery Section Body Doc Link PMC2840903 Disease Relevance 1.08 Pain Relevance 0.43
The likelihood of altered employment (P < 0.0006), reduced productivity (P < 0.0001), and seeking disability benefits (P < 0.003) was significantly associated with the presence of neck pain, but not type of employment, spasmodic head motions, or duration of CD symptoms before treatment with BTx.
BTx Binding (associated) of in head associated with pain, cervical cancer and neck pain
16) Confidence 0.30 Published 2009 Journal Mov. Disord. Section Abstract Doc Link 19441129 Disease Relevance 0.75 Pain Relevance 0.18
These sites could be differentiated by means of the divalent cations Mg2+ and Ca2+, that inhibit BTX-B binding completely.
BTX-B Binding (binding) of
17) Confidence 0.29 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2450762 Disease Relevance 0 Pain Relevance 0.38
The rank order of potency of the local anesthetics as antagonists of [3H]BTX-B binding was as follows: dibucaine greater than tetracaine greater than bupivacaine greater than diphenhydramine greater than piperocaine greater than cocaine greater than procaine greater than lidocaine greater than benzocaine.
BTX-B Binding (binding) of associated with antagonist, lidocaine, cocaine, local anesthetic and potency
18) Confidence 0.28 Published 1983 Journal Mol. Pharmacol. Section Abstract Doc Link 6300644 Disease Relevance 0 Pain Relevance 1.02
The rank order and relative potency of the local anesthetics tested in both paradigms were similar with the exception of lidocaine ethiodide, which was 18 times more potent as an inhibitor of binding of [3H]BTX-B than it was as an inhibitor of BTX-elicited depolarization.
BTX-B Binding (binding) of associated with lidocaine, local anesthetic and potency
19) Confidence 0.28 Published 1983 Journal Mol. Pharmacol. Section Abstract Doc Link 6300644 Disease Relevance 0 Pain Relevance 0.83
A series of 14 local anesthetics was shown to inhibit the specific binding of [3H]BTX-B with Ki values ranging from 0.6 microM for dibucaine to 400 microM for benzocaine.
BTX-B Binding (binding) of associated with local anesthetic
20) Confidence 0.28 Published 1983 Journal Mol. Pharmacol. Section Abstract Doc Link 6300644 Disease Relevance 0 Pain Relevance 0.91

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