INT233304

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.93
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SRY) DNA binding (SRY) transmembrane transport (SLC22A8)
cytoplasm (SRY) transmembrane transporter activity (SLC22A8) nucleus (SRY)
Anatomy Link Frequency
plasma 1
SRY (Homo sapiens)
SLC22A8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 4 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 16 97.76 Very High Very High Very High
Hepatomegaly 1 88.32 High High
Lactic Acidosis 1 87.64 High High
Adverse Drug Reaction 4 82.84 Quite High
Syndrome 1 74.32 Quite High
Injury 1 72.40 Quite High
Hypophosphatemia 1 70.88 Quite High
Glycosuria 2 68.00 Quite High
Hyperkalemia 1 66.32 Quite High
Renal Disease 2 62.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like the known nephrotoxic NtRTIs cidofovir and adefovir, TDF is extracted from the blood plasma by the human renal organic anion transporters (hOAT1 and hOAT3), which has suggested the possibility of renal tubular toxicity (Uwai et al 2007).
TDF Binding (extracted) of hOAT3 in plasma associated with toxicity
1) Confidence 0.34 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387297 Disease Relevance 0.93 Pain Relevance 0

General Comments

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