INT233349

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.71
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12b) extracellular region (Il12b) cytoplasm (Il12b)
Anatomy Link Frequency
granulocyte 1
macrophages 1
poly 1
neutrophils 1
Il12b (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 60 96.96 Very High Very High Very High
cytokine 123 96.52 Very High Very High Very High
chemokine 26 89.28 High High
Inflammation 24 5.00 Very Low Very Low Very Low
Multiple sclerosis 21 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Spinal cord 10 5.00 Very Low Very Low Very Low
Demyelination 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
peptic ulcer disease 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 50 100.00 Very High Very High Very High
Mycobacterial Infection 340 98.88 Very High Very High Very High
Infection 158 98.36 Very High Very High Very High
Paralysis 4 89.92 High High
Influenza Virus Infection 92 88.72 High High
Repression 42 88.16 High High
Sprains And Strains 83 81.52 Quite High
Multiple Sclerosis 92 75.00 Quite High
Coccidioides Infection 3 66.96 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 47.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-12p70–driven disease was characterized by macrophage-rich infiltrates and prominent NOS2 up-regulation, whereas neutrophils and granulocyte–colony-stimulating factor (CSF) were prominent in IL-23–driven lesions.
Regulation (regulation) of IL-12p70 in granulocyte associated with disease
1) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2442630 Disease Relevance 0.48 Pain Relevance 0.37
The differences in cytokine production observed for macrophages treated with TDM-containing oxygenated mycolic acids versus mutant TDMs lacking oxygenated mycolic acids suggested a possible inhibitory effect of the oxygenated mycolic acids on IL-12p40 responses.
Spec (possible) Regulation (effect) of IL-12p40 in macrophages associated with cytokine
2) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.31 Pain Relevance 0.21
The attenuation of virulence was reversed in IL-12p40-deficient mice, indicating that this attenuation depended on IL-12p40-mediated immunity.
Regulation (depended) of IL-12p40-mediated
3) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.65 Pain Relevance 0.04
Since the cis elements required for regulation of the IL-12p40 promoter in response to M. tuberculosis infection are not known, we engineered another Raw 264.7 line containing a stable integration of the full-length IL-12p40 promoter fused to GFP.
Regulation (regulation) of IL-12p40 associated with mycobacterial infection and infection
4) Confidence 0.03 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 1.02 Pain Relevance 0
IL-12p70–driven disease was characterized by macrophage-rich infiltrates and prominent NOS2 up-regulation, whereas neutrophils and granulocyte–colony-stimulating factor (CSF) were prominent in IL-23–driven lesions.
Regulation (regulation) of IL-12p70 in neutrophils associated with disease
5) Confidence 0.02 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2442630 Disease Relevance 0.48 Pain Relevance 0.37
Treatment with vaccine plus poly (IC) rapidly up-regulated TLR3 expression in the nasal-associated lymphoid tissue, up-regulated IL-4 and IL-12p40, and induced IFN-?
Regulation (regulated) of IL-12p40 in poly
6) Confidence 0.00 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.77 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox