INT233349

Context Info Confidence 0.05 First Reported 2008 Last Reported 2008 Negated 0 Speculated 1 Reported most in Body Documents 5 Total Number 6 Disease Relevance 3.71 Pain Relevance 0.98

extracellular space (Il12b) extracellular region (Il12b) cytoplasm (Il12b)

Anatomy Link Frequency granulocyte 1 macrophages 1 poly 1 neutrophils 1 Il12b (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 60 96.96 cytokine 123 96.52 chemokine 26 89.28 Inflammation 24 5.00 Multiple sclerosis 21 5.00 agonist 12 5.00 Spinal cord 10 5.00 Demyelination 4 5.00 fibrosis 3 5.00 peptic ulcer disease 3 5.00

Disease Link Frequency Relevance Heat Disease 50 100.00 Mycobacterial Infection 340 98.88 Infection 158 98.36 Paralysis 4 89.92 Influenza Virus Infection 92 88.72 Repression 42 88.16 Sprains And Strains 83 81.52 Multiple Sclerosis 92 75.00 Coccidioides Infection 3 66.96 Acquired Immune Deficiency Syndrome Or Hiv Infection 7 47.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IL-12p70–driven disease was characterized by macrophage-rich infiltrates and prominent NOS2 up-regulation, whereas neutrophils and granulocyte–colony-stimulating factor (CSF) were prominent in IL-23–driven lesions.

Regulation (regulation) of IL-12p70 in granulocyte associated with disease

1) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2442630 Disease Relevance 0.48 Pain Relevance 0.37

The differences in cytokine production observed for macrophages treated with TDM-containing oxygenated mycolic acids versus mutant TDMs lacking oxygenated mycolic acids suggested a possible inhibitory effect of the oxygenated mycolic acids on IL-12p40 responses.

Spec (possible) Regulation (effect) of IL-12p40 in macrophages associated with cytokine

2) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.31 Pain Relevance 0.21

The attenuation of virulence was reversed in IL-12p40-deficient mice, indicating that this attenuation depended on IL-12p40-mediated immunity.

Regulation (depended) of IL-12p40-mediated

3) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.65 Pain Relevance 0.04

Since the cis elements required for regulation of the IL-12p40 promoter in response to M. tuberculosis infection are not known, we engineered another Raw 264.7 line containing a stable integration of the full-length IL-12p40 promoter fused to GFP.

Regulation (regulation) of IL-12p40 associated with mycobacterial infection and infection

4) Confidence 0.03 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 1.02 Pain Relevance 0

IL-12p70–driven disease was characterized by macrophage-rich infiltrates and prominent NOS2 up-regulation, whereas neutrophils and granulocyte–colony-stimulating factor (CSF) were prominent in IL-23–driven lesions.

Regulation (regulation) of IL-12p70 in neutrophils associated with disease

5) Confidence 0.02 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2442630 Disease Relevance 0.48 Pain Relevance 0.37

Treatment with vaccine plus poly (IC) rapidly up-regulated TLR3 expression in the nasal-associated lymphoid tissue, up-regulated IL-4 and IL-12p40, and induced IFN-?

Regulation (regulated) of IL-12p40 in poly

6) Confidence 0.00 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.77 Pain Relevance 0

General Comments

This test has worked.