INT233397

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.59
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL2A1) transport (ABCA4) extracellular region (COL2A1)
ATPase activity (ABCA4) plasma membrane (ABCA4) cytoplasm (COL2A1)
Anatomy Link Frequency
eye 2
ABCA4 (Homo sapiens)
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 5 55.68 Quite High
Inflammation 10 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Neuritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Toxoplasmosis 140 100.00 Very High Very High Very High
Eye Disease 105 100.00 Very High Very High Very High
Toxoplasmosis 50 99.40 Very High Very High Very High
Infection 95 96.56 Very High Very High Very High
Brain Disease 50 92.56 High High
Disease 155 88.96 High High
Chorioretinitis 15 74.32 Quite High
Genetic Predisposition To Disease 10 67.84 Quite High
Epstein-barr Virus 70 66.92 Quite High
Necrosis 5 61.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These associations between clinical outcomes of congenital toxoplasmosis and polymorphisms at ABCA4 and COL2A1 provide novel insight into the molecular pathways that can be affected by congenital infection with this parasite.



ABCA4 Binding (associations) of COL2A1 associated with congenital toxoplasmosis and infection
1) Confidence 0.38 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2390765 Disease Relevance 1.05 Pain Relevance 0
Overall, the evidence from the children with eye and brain signs associated with congenitally acquired toxoplasmosis in these two cohorts was for association with eye disease and these two previously recognized eye disorder genes, ABCA4 and COL2A1.
ABCA4 Binding (association) of COL2A1 in eye associated with eye disease and toxoplasmosis
2) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.48 Pain Relevance 0
Overall, the evidence from the children with eye and brain signs associated with congenitally acquired toxoplasmosis in these two cohorts was for association with eye disease and these two previously recognized eye disorder genes, ABCA4 and COL2A1.
ABCA4 Binding (recognized) of COL2A1 in eye associated with eye disease and toxoplasmosis
3) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.47 Pain Relevance 0
We chose to look specifically for associations with ABCA4 and COL2A1 (a) because both had defined single gene disorders that result in congenital or early onset ocular disease; and (b) some parallels in clinical pathology or putative pathogenic mechanisms could be drawn between the genetic disorders and ocular disease induced by T. gondii infection in utero.
ABCA4 Binding (associations) of COL2A1 associated with infection and eye disease
4) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 1.15 Pain Relevance 0.03
Herein we examined the specific genetic hypothesis that polymorphisms in two genes known to be associated with ocular disease, ABCA4 and COL2A1, are associated with ocular disease caused by congenital toxoplasmosis.
ABCA4 Spec (examined) Binding (associated) of COL2A1 associated with congenital toxoplasmosis and eye disease
5) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.44 Pain Relevance 0

General Comments

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