INT233399

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 9.49
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA4) ATPase activity (ABCA4) plasma membrane (ABCA4)
transmembrane transport (ABCA4)
Anatomy Link Frequency
eye 2
photoreceptor 1
juvenile 1
muscle 1
brain 1
ABCA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 9 84.16 Quite High
adenocard 3 43.12 Quite Low
Inflammation 19 35.04 Quite Low
Osteoarthritis 16 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Neuritis 8 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 304 100.00 Very High Very High Very High
Congenital Toxoplasmosis 224 100.00 Very High Very High Very High
Eye Disease 168 100.00 Very High Very High Very High
Brain Disease 80 99.42 Very High Very High Very High
Toxoplasmosis 80 99.40 Very High Very High Very High
Retinal Dystrophies 16 99.16 Very High Very High Very High
Glaucoma 18 99.08 Very High Very High Very High
Cataract 17 98.52 Very High Very High Very High
Retina Disease 57 98.12 Very High Very High Very High
Obesity 128 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, the evidence from the children with eye and brain signs associated with congenitally acquired toxoplasmosis in these two cohorts was for association with eye disease and these two previously recognized eye disorder genes, ABCA4 and COL2A1.
ABCA4 Binding (recognized) of in eye associated with eye disease and toxoplasmosis
1) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.47 Pain Relevance 0
Overall, the evidence from the children with eye and brain signs associated with congenitally acquired toxoplasmosis in these two cohorts was for association with eye disease and these two previously recognized eye disorder genes, ABCA4 and COL2A1.
ABCA4 Binding (association) of in eye associated with eye disease and toxoplasmosis
2) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.48 Pain Relevance 0
For the EMSCOT cohort, no significant associations were observed for any SNPs at ABCA4 or COL2A1 when congenitally infected children of mothers with primary gestational infection were compared with children of mothers with primary gestational infection who did not transmit infection to the fetus (Table 1 and data not shown).
ABCA4 Neg (no) Binding (associations) of associated with infection
3) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 1.10 Pain Relevance 0
Genetic disorders of ABCA4 are associated with juvenile onset retinal dystrophies including Stargardt's disease.
ABCA4 Binding (associated) of in juvenile associated with disease and retinal dystrophies
4) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 2.23 Pain Relevance 0.04
These associations between clinical outcomes of congenital toxoplasmosis and polymorphisms at ABCA4 and COL2A1 provide novel insight into the molecular pathways that can be affected by congenital infection with this parasite.



ABCA4 Binding (associations) of associated with congenital toxoplasmosis and infection
5) Confidence 0.34 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2390765 Disease Relevance 1.05 Pain Relevance 0
We chose to look specifically for associations with ABCA4 and COL2A1 (a) because both had defined single gene disorders that result in congenital or early onset ocular disease; and (b) some parallels in clinical pathology or putative pathogenic mechanisms could be drawn between the genetic disorders and ocular disease induced by T. gondii infection in utero.
ABCA4 Binding (associations) of associated with infection and eye disease
6) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 1.14 Pain Relevance 0.03
Herein we examined the specific genetic hypothesis that polymorphisms in two genes known to be associated with ocular disease, ABCA4 and COL2A1, are associated with ocular disease caused by congenital toxoplasmosis.
ABCA4 Spec (examined) Binding (associated) of associated with congenital toxoplasmosis and eye disease
7) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.43 Pain Relevance 0
STGD is clinically characterized by RPE and photoreceptor inner segment lipofuscin accumulation, RPE and choroidal vascular atrophy, macular photoreceptor loss, and reactive Müller glial hypertrophy [37,38] with progressive loss of central visual acuity during the first two decades [21].
STGD Binding (characterized) of in photoreceptor associated with hypertrophy, frailty and disease
8) Confidence 0.30 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.10 Pain Relevance 0
In 457 mother-child pairs from Europe, and 149 child/parent trios from North America, we show that ocular and brain disease in congenital toxoplasmosis associate with polymorphisms in ABCA4 encoding ATP-binding cassette transporter, subfamily A, member 4.
ABCA4 Binding (associate) of in brain associated with brain disease and congenital toxoplasmosis
9) Confidence 0.30 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2390765 Disease Relevance 1.25 Pain Relevance 0
While these studies were conducted in older adults, the association between BMI, FFM, muscle qualities, and physical function in children remains unknown.
FFM Binding (association) of in muscle
10) Confidence 0.25 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2990021 Disease Relevance 0.24 Pain Relevance 0

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