INT233419

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.97
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Egfr) cell morphogenesis (Egfr) intracellular (Egfr)
enzyme binding (Egfr) cytoplasm (Egfr) signal transducer activity (Egfr)
Egfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal excitability 14 71.60 Quite High
Neurotransmitter 5 65.32 Quite High
repetitive firing 1 53.36 Quite High
substance P 1 52.32 Quite High
bradykinin 1 47.60 Quite Low
Inflammation 7 30.56 Quite Low
chemokine 1 29.52 Quite Low
potassium channel 1 25.44 Quite Low
Nerve growth factor 126 22.56 Low Low
Hippocampus 1 15.28 Low Low
Disease Link Frequency Relevance Heat
Colon Cancer 9 95.52 Very High Very High Very High
Disease 1 91.32 High High
Lung Cancer 1 85.72 High High
Squamous Cell Neoplasms 1 83.60 Quite High
Solid Tumor 2 81.32 Quite High
Apoptosis 2 78.48 Quite High
Epilepsy 3 77.04 Quite High
Adhesions 1 68.84 Quite High
Exanthema 35 57.52 Quite High
Wound Healing 1 38.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
to block ligand-dependant activation of EGFR, and induce receptor internalization and consequent downregulation19.
Negative_regulation (block) of Positive_regulation (activation) of EGFR
1) Confidence 0.40 Published 2010 Journal Current Oncology Section Body Doc Link PMC2901793 Disease Relevance 0.90 Pain Relevance 0
In the case of receptor tyrosine kinases (RTKs), activation of the epidermal growth factor receptor inhibits M/KCNQ currents through the two distinct mechanisms of membrane PtdIns(4,5)P2 hydrolysis and tyrosine phosphorylation of the channel (Jia et al., 2007).
Negative_regulation (inhibits) of Positive_regulation (activation) of epidermal growth factor receptor
2) Confidence 0.16 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2391251 Disease Relevance 0.08 Pain Relevance 0.12

General Comments

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