INT23344

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Context Info
Confidence 0.75
First Reported 1983
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 60
Total Number 62
Disease Relevance 28.20
Pain Relevance 13.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
brain 9
neurons 5
leukocyte 3
Uterine 2
blood 2
Alox5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 100.00 Very High Very High Very High
qutenza 51 99.96 Very High Very High Very High
Hyperalgesia 26 99.96 Very High Very High Very High
bradykinin 15 99.68 Very High Very High Very High
Central nervous system 3 99.68 Very High Very High Very High
Enkephalin 2 99.36 Very High Very High Very High
cINOD 58 99.34 Very High Very High Very High
ischemia 430 99.28 Very High Very High Very High
Hyperesthesia 1 99.22 Very High Very High Very High
c fibre 3 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Mastocytoma 1 100.00 Very High Very High Very High
Hyperalgesia 32 99.96 Very High Very High Very High
Reperfusion Injury 2 99.66 Very High Very High Very High
Injury 478 99.58 Very High Very High Very High
Stroke 348 99.50 Very High Very High Very High
Cv Unclassified Under Development 268 99.28 Very High Very High Very High
INFLAMMATION 683 99.12 Very High Very High Very High
Pain 14 99.12 Very High Very High Very High
Erythema 1 98.98 Very High Very High Very High
Pressure And Volume Under Development 46 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence for the involvement of 5-lipoxygenase products in the regulation of the expression of the proenkephalin gene in cultured astroglial cells.
Gene_expression (products) of 5-lipoxygenase associated with enkephalin
1) Confidence 0.75 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8774948 Disease Relevance 0 Pain Relevance 0.14
Rosiglitazone induced brain 5-lipoxygenase (5-LO) expression in ischemic rat brain, concomitantly with neuroprotection.
Gene_expression (expression) of 5-lipoxygenase in brain
2) Confidence 0.75 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321784 Disease Relevance 0.70 Pain Relevance 0.20
Cellular production of 5-lipoxygenase products was inhibited by SK&F 86002 as measured by leukotriene B4 (LTB4) generation from human neutrophils (IC50 20 microM), leukotriene C4 (LTC4) generation by human monocytes (IC50 20 microM), and 5-HETE production by RBL-1 cells (IC50 40 microM).
Gene_expression (production) of 5-lipoxygenase in neutrophils
3) Confidence 0.75 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 2823821 Disease Relevance 0.52 Pain Relevance 0.23
Naproxen, ibuprofen or piroxicam 1 or 10 micrograms ml-1 resulted in smaller increases of lipoxygenase products, and there was only a small rise with these concentrations of isoxicam.
Gene_expression (products) of lipoxygenase
4) Confidence 0.67 Published 1985 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2864427 Disease Relevance 0.16 Pain Relevance 0.20
At the lowest concentration tested (1 microgram ml-1), indomethacin markedly increased the accumulation of lipoxygenase products in the cell incubates.
Gene_expression (products) of lipoxygenase
5) Confidence 0.67 Published 1985 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2864427 Disease Relevance 0.17 Pain Relevance 0.21
We report 5-LOX expression in the central nervous system (CNS) and analyze the pain efficacy of a new class of non redox, non iron chelating 5-LOX inhibitor.
Gene_expression (expression) of 5-LOX in central nervous system associated with pain and central nervous system
6) Confidence 0.66 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19580807 Disease Relevance 0.57 Pain Relevance 0.57
L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3-methyl-5-propyl-4-benzofuranol) was a potent inhibitor of leukotriene biosynthesis in intact rat and human leukocytes and CXBG mastocytoma cells (IC50 values, 18-240 nM) and of crude human leukocyte and highly purified porcine leukocyte 5-lipoxygenase (IC50 value, 4 X 10(-7) M).
Gene_expression (biosynthesis) of 5-lipoxygenase in leukocyte associated with mastocytoma
7) Confidence 0.65 Published 1987 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2835137 Disease Relevance 0.25 Pain Relevance 0.13
It is concluded that in astroglial cells derived from cortex of new-born rats products of 5-lipoxygenase can diminish the action of protein kinase C on the proenkephalin gene.
Gene_expression (products) of 5-lipoxygenase in cortex associated with kinase c
8) Confidence 0.65 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8774948 Disease Relevance 0 Pain Relevance 0.08
Evaluation of 5-LOX metabolites-by LC/MS/MS and ELISA confirmed that both compounds selectively inhibited all products downstream of 5-hydroperoxy eicosatetraenoic acid (5-HPETE), including 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxoETE), without inhibition of 12-lipoxygenase (12-LOX), 15-lipoxygenase (15-LOX), or cyclooxygenase (COX) products.
Gene_expression (products) of 5-lipoxygenase
9) Confidence 0.65 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18295198 Disease Relevance 0 Pain Relevance 0.04
Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent, neuroprotective effects of rosiglitazone in experimental stroke.
Gene_expression (Synthesis) of 5-lipoxygenase associated with stroke
10) Confidence 0.65 Published 2009 Journal J. Neurosci. Section Title Doc Link 19321784 Disease Relevance 0.61 Pain Relevance 0.15
All of these results suggest that an overproduction of leukotrienes and other lipoxygenase products, following cyclooxygenase blockade induced by NSAIDs, may play a role in the development of gastric mucosal damage.
Gene_expression (products) of lipoxygenase associated with cinod
11) Confidence 0.64 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8369011 Disease Relevance 0.16 Pain Relevance 0.30
To investigate the hypothesis that the gastric damage caused by NSAIDs is due not only to the decreased level of cyclooxygenase products but to the increased level of lipoxygenase products as well, different lipoxygenase inhibitors and leukotriene antagonists were tested.
Gene_expression (products) of lipoxygenase associated with antagonist and cinod
12) Confidence 0.55 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8369011 Disease Relevance 0.22 Pain Relevance 0.35
The acetylated COX-2 remains active, and upon cell activation, initiates the generation of 15R-HETE, a lipid substrate for 5-lipoxygenase (LOX) leading to the formation of 15-epi-LXA4 (also termed "aspirin-triggered lipoxin," or ATL).
Gene_expression (generation) of 5-lipoxygenase associated with aspirin and htlv types i and ii
13) Confidence 0.51 Published 2003 Journal FASEB J. Section Abstract Doc Link 12709408 Disease Relevance 0.37 Pain Relevance 0.23
We conclude that (1) islet lipoxygenase is constitutively expressed and is not physiologically regulated by alpha 2-adrenergic agonism, Ca2+ or protein kinases; (2) lipoxygenase modulates insulin release; HETE production is not merely an epiphenomenon reflecting the activation (or inhibition) of exocytotic secretion; (3) islet lipoxygenase inhibitors reduce insulin secretion, at least in part, by blocking the direct effects of Ca2+ on exocytosis and/or its synergism with Ca2+-binding proteins such as protein kinase C; and (4) these same inhibitors do not directly poison protein kinase C or A, or the exocytotic apparatus.
Gene_expression (expressed) of lipoxygenase associated with kinase c and poisoning
14) Confidence 0.50 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2567595 Disease Relevance 0.08 Pain Relevance 0.30
Beside the decreased level of the so-called cytoprotective prostaglandins caused by the inhibition of cyclooxygenase enzyme an overproduction of 5-lipoxygenase products (leukotrienes) was also found.
Gene_expression (products) of lipoxygenase
15) Confidence 0.48 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8369011 Disease Relevance 0.21 Pain Relevance 0.29
Beside the decreased level of the so-called cytoprotective prostaglandins caused by the inhibition of cyclooxygenase enzyme an overproduction of 5-lipoxygenase products (leukotrienes) was also found.
Gene_expression (overproduction) of lipoxygenase
16) Confidence 0.48 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8369011 Disease Relevance 0.21 Pain Relevance 0.29
LO products are endogenous TRPV1 activators and pretreatment with BCTC, a TRPV1 antagonist inhibited the thermal but not the mechanical hypersensitivity.
Gene_expression (products) of LO associated with antagonist and hypersensitivity
17) Confidence 0.47 Published 2009 Journal Mol. Cells Section Abstract Doc Link 19390822 Disease Relevance 0.57 Pain Relevance 0.40
Overall, our results from the Fos-LI and behavior tests suggest that LO products released from inflamed tissues contribute to nociception during carrageenan-induced inflammation, indicating that the LO pathway is a possible target for modulating inflammatory pain.
Gene_expression (products) of LO associated with nociception, inflammation and ipn
18) Confidence 0.47 Published 2009 Journal Mol. Cells Section Abstract Doc Link 19390822 Disease Relevance 0.75 Pain Relevance 0.41
In addition, in the presence of the calcium inophore A23187 or the non-ionic detergent, BRIJ 56, rat neutrophils also produce the lipoxygenase products 5-hydroxy-icosatetraenoic acid and leukotriene B.
Gene_expression (produce) of lipoxygenase in neutrophils
19) Confidence 0.46 Published 1983 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 6221723 Disease Relevance 0.30 Pain Relevance 0.14
The decreased relaxation by BK in anococcygeus muscle did not occur by the release of cyclooxygenase products or tachykinins from tracheal epithelium, but it may have occurred by the contractile action of lipoxygenase product secreted by nonepithelial sources.
Gene_expression (product) of lipoxygenase in epithelium associated with bradykinin
20) Confidence 0.43 Published 1998 Journal Gen. Pharmacol. Section Abstract Doc Link 9522162 Disease Relevance 0 Pain Relevance 0.46

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