INT233452

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 12
Disease Relevance 1.91
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccrl2) plasma membrane (Ccrl2) signal transducer activity (Ccrl2)
Anatomy Link Frequency
mast cells 6
peritoneal macrophages 2
Ccrl2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 334 95.60 Very High Very High Very High
Inflammation 102 81.52 Quite High
Multiple sclerosis 12 79.80 Quite High
Central nervous system 2 50.40 Quite High
Inflammatory response 42 26.64 Quite Low
cytokine 62 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Potency 20 5.00 Very Low Very Low Very Low
ketamine 10 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaphylaxis 290 99.34 Very High Very High Very High
Edema 190 83.52 Quite High
INFLAMMATION 152 81.52 Quite High
Demyelinating Disease 12 79.80 Quite High
Multiple Sclerosis 12 78.68 Quite High
Shock 2 74.40 Quite High
Apoptosis 2 34.32 Quite Low
Mycobacterial Infection 6 27.24 Quite Low
Contact Dermatitis 70 7.28 Low Low
Disease 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (levels) of Gene_expression (expressed) of Ccrl2
1) Confidence 0.42 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.16
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (elevated) of Gene_expression (expressed) of Ccrl2
2) Confidence 0.42 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.18
However, at 6 h after antigen challenge, IgE-dependent PCA reactions in ears that had been engrafted with CCRL2 KO mast cells contained ?
Positive_regulation (engrafted) of Gene_expression (mast cells) of CCRL2 in mast cells associated with anaphylaxis
3) Confidence 0.36 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.51 Pain Relevance 0
However, at 6 h after antigen challenge, IgE-dependent PCA reactions in ears that had been engrafted with CCRL2 KO mast cells contained ?
Positive_regulation (with) of Gene_expression (mast cells) of CCRL2 in mast cells associated with anaphylaxis
4) Confidence 0.36 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.51 Pain Relevance 0
mCMKLR1-HA and mCCRL2-HA L1.2 transfectants were loaded for 30 min on ice with primary antibody (anti-HA or mIgG1 isotype control).
Positive_regulation (transfectants) of Gene_expression (transfectants) of mCCRL2-HA
5) Confidence 0.32 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
For competition binding assays, L1.2 cells transfected with huCCRL2, mCCRL2, or mCMKLR1 were plated into 96-well plates at 0.5 × 106 cells/well.
Positive_regulation (transfected) of Gene_expression (transfected) of mCCRL2
6) Confidence 0.32 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
mCMKLR1-HA, huCCRL2-HA, and mCCRL2-HA L1.2 transfectants were incubated for 15 min with 100 nM serum form chemerin at the indicated temperature in cell culture media.
Positive_regulation (incubated) of Gene_expression (transfectants) of mCCRL2-HA
7) Confidence 0.32 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
For competition binding assays, L1.2 cells transfected with huCCRL2, mCCRL2, or mCMKLR1 were plated into 96-well plates at 0.5 × 106 cells/well.
Positive_regulation (transfected) of Gene_expression (transfected) of huCCRL2
8) Confidence 0.32 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
mCMKLR1-HA, huCCRL2-HA, and mCCRL2-HA L1.2 transfectants were incubated for 15 min with 100 nM serum form chemerin at the indicated temperature in cell culture media.
Positive_regulation (incubated) of Gene_expression (transfectants) of huCCRL2-HA
9) Confidence 0.32 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
In agreement with published RNA expression data (3), peritoneal macrophages treated with LPS up-regulated mCCRL2 protein expression.
Positive_regulation (up-regulated) of Gene_expression (expression) of mCCRL2 in peritoneal macrophages
10) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.14 Pain Relevance 0.03
Expression of mCCRL2 was also up-regulated in such cells by treatment with TNF?
Positive_regulation (up-regulated) of Gene_expression (Expression) of mCCRL2
11) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.13 Pain Relevance 0
Mast cells derived from BM progenitors in vitro (BMCMCs) up-regulated expression of mCCRL2 over time in culture.
Positive_regulation (up-regulated) of Gene_expression (expression) of mCCRL2 in Mast cells
12) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0

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