INT233453

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Context Info
Confidence 0.74
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 15
Disease Relevance 8.45
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Itm2b) plasma membrane (Itm2b) nucleus (Itm2b)
Anatomy Link Frequency
neurons 3
BMM 1
blood vessels 1
TEPM 1
Itm2b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 42 96.12 Very High Very High Very High
chemokine 14 93.40 High High
Spinal cord 32 89.68 High High
Thalamus 16 89.04 High High
Hippocampus 16 88.16 High High
Inflammation 85 87.80 High High
cerebral cortex 24 87.64 High High
Multiple sclerosis 7 77.60 Quite High
Central nervous system 15 74.24 Quite High
Inflammatory stimuli 28 52.32 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 216 100.00 Very High Very High Very High
Alzheimer's Dementia 168 99.72 Very High Very High Very High
Dementia 360 99.66 Very High Very High Very High
Cerebral Amyloid Angiopathy 8 98.12 Very High Very High Very High
INFLAMMATION 155 95.72 Very High Very High Very High
Gliosis 8 94.72 High High
Amyloidosis 32 94.16 High High
Ataxia 24 92.96 High High
Disease 79 86.32 High High
Mycobacterial Infection 21 84.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
region of the BRI2 gene, right before the stop codon, leads as well to the production of a longer, 277 aa protein (BRI2-ADan) [3].
Gene_expression (production) of BRI2-ADan
1) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 1.72 Pain Relevance 0.18
The absence of this band in the BRI2ADan/ADan neurons is attributable to the fact that these cells have both BRI2 alleles mutated. 3) As expected, the BRI2ADan/wt sample expresses all three BRI2 polypeptides, i.e. wild type imBRI2, BRI2-ADan precursor and mBRI2.
Gene_expression (expresses) of BRI2 in neurons
2) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 0.41 Pain Relevance 0
To clone the ADan mutation allele, a fragment obtained form BAC (containing mouse BRI2 genome) was amplified by PCR with the following primers:
Gene_expression (genome) of BRI2
3) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 0.56 Pain Relevance 0
We have generated the first BRI2 Danish Knock-In (FDDKI) murine model of FDD, expressing the pathogenic decamer duplication in exon 6 of the BRI2 gene.
Gene_expression (expressing) of BRI2 associated with targeted disruption
4) Confidence 0.56 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2774945 Disease Relevance 0.82 Pain Relevance 0
A transgenic FDD model which over-expresses the Danish mutant form of BRI2 shows amyloid deposition in the walls of blood vessels of the cerebrum and cerebellum, parenchymal amyloid deposition and reactive gliosis, ADan amyloidosis and some signs of cerebellar ataxia [20].
Gene_expression (expresses) of BRI2 in blood vessels associated with targeted disruption, ataxia, amyloidosis, dementia, alzheimer's dementia and gliosis
5) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 1.43 Pain Relevance 0
The absence of this band in the BRI2ADan/ADan neurons is attributable to the fact that these cells have both BRI2 alleles mutated. 3) As expected, the BRI2ADan/wt sample expresses all three BRI2 polypeptides, i.e. wild type imBRI2, BRI2-ADan precursor and mBRI2.
Gene_expression (expresses) of imBRI2 in neurons
6) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 0.46 Pain Relevance 0
For comparison, we included sections of an age-matched female FDD-Tg mouse, which expresses the Danish mutant form of human BRI2 under the mouse prion protein promoter [20].
Gene_expression (expresses) of BRI2 associated with dementia
7) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 1.05 Pain Relevance 0.25
The absence of this band in the BRI2ADan/ADan neurons is attributable to the fact that these cells have both BRI2 alleles mutated. 3) As expected, the BRI2ADan/wt sample expresses all three BRI2 polypeptides, i.e. wild type imBRI2, BRI2-ADan precursor and mBRI2.
Gene_expression (expresses) of BRI2-ADan in neurons
8) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 0.46 Pain Relevance 0
It is therefore unlikely that the differential expression of these genes in BMM versus TEPM is a reflection of the proliferative state of the cells.
Gene_expression (expression) of BMM
9) Confidence 0.02 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.13 Pain Relevance 0.07
We then compared the GPCR expression profiles of BMM and TEPM to the remaining panel of cell types, and in doing so, identified 67 GPCRs that were detectably expressed either constitutively or in an LPS-induced manner in these primary macrophage populations [see additional file 1].
Gene_expression (expression) of BMM in TEPM
10) Confidence 0.02 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.17 Pain Relevance 0.05
As an example, figure 2a and 2b demonstrate the selective expression of Calcrl and Gprc5b in BMM and TEPM, respectively.
Gene_expression (expression) of BMM
11) Confidence 0.02 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.17 Pain Relevance 0.09
Nonetheless, there were also GPCRs that had distinct expression levels in BMM versus TEPM, as well as BMM versus RAW264.
Gene_expression (expression) of BMM
12) Confidence 0.02 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.14 Pain Relevance 0.07
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Gene_expression (expressed) of BMM
13) Confidence 0.02 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.16
In BMM, Prokr1 was transiently induced by LPS (37-fold at 6 h) but repressed in TEPM (20-fold at 7 h).
Gene_expression (repressed) of BMM
14) Confidence 0.01 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.44 Pain Relevance 0.07
We then compared the GPCR expression profiles of BMM and TEPM to the remaining panel of cell types, and in doing so, identified 67 GPCRs that were detectably expressed either constitutively or in an LPS-induced manner in these primary macrophage populations [see additional file 1].
Gene_expression (expression) of BMM in BMM
15) Confidence 0.01 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.17 Pain Relevance 0.05

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