INT233456

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Context Info
Confidence 0.66
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.74
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry6) plasma membrane (P2ry6) signal transducer activity (P2ry6)
Anatomy Link Frequency
osteoclasts 2
macrophages 1
dendritic cells 1
P2ry6 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 13 99.84 Very High Very High Very High
Inflammation 49 96.20 Very High Very High Very High
nociceptor 44 92.04 High High
Inflammatory response 24 87.84 High High
agonist 28 86.80 High High
Hyperalgesia 6 83.36 Quite High
Pain 4 82.68 Quite High
Inflammatory stimuli 16 78.76 Quite High
c fibre 19 76.24 Quite High
antagonist 11 74.24 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 13 99.84 Very High Very High Very High
Nociception 6 97.56 Very High Very High Very High
INFLAMMATION 89 96.20 Very High Very High Very High
Injury 8 95.52 Very High Very High Very High
Hyperalgesia 6 83.36 Quite High
Pain 2 82.68 Quite High
Hypoxia 4 80.88 Quite High
Stress 4 77.20 Quite High
Rheumatoid Arthritis 34 15.52 Low Low
Mycobacterial Infection 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As demonstrated in figure 1b, P2ry6 expression was strikingly restricted to macrophages and two cell types closely related to macrophages (osteoclasts and dendritic cells), whilst a number of other P2Y family receptors were also highly expressed by this lineage (Table 2).
Gene_expression (expression) of P2ry6 in dendritic cells
1) Confidence 0.66 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0 Pain Relevance 0
Whilst no previous studies have indicated that P2ry6 expression is restricted to the monocyte/macrophage lineage, there is evidence to suggest that this receptor does regulate the function of macrophages.
Gene_expression (expression) of P2ry6 in macrophages
2) Confidence 0.51 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.43 Pain Relevance 0.19
P2ry6 expression in osteoclasts, which are a closely related lineage to macrophages, has been confirmed by others [21].
Gene_expression (expression) of P2ry6 in osteoclasts
3) Confidence 0.51 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.47 Pain Relevance 0.18
Four P2Y receptor subtypes (P2Y1, P2Y2, P2Y4 and P2Y6) have been detected in DRG neurones (Gerevich & Illes, 2004), but their role in nociception has only just begun to be investigated (Gerevich & Illes, 2004; Malin et al. 2008).
Gene_expression (detected) of P2Y6 associated with nociception and dorsal root ganglion
4) Confidence 0.28 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.85 Pain Relevance 0.68
As demonstrated in figure 1b, P2ry6 expression was strikingly restricted to macrophages and two cell types closely related to macrophages (osteoclasts and dendritic cells), whilst a number of other P2Y family receptors were also highly expressed by this lineage (Table 2).
Gene_expression (expression) of P2ry6 in osteoclasts
5) Confidence 0.22 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0 Pain Relevance 0

General Comments

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