INT233457

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 56
Total Number 57
Disease Relevance 26.57
Pain Relevance 27.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr65) plasma membrane (Gpr65) signal transducer activity (Gpr65)
Anatomy Link Frequency
neurons 31
IB4 5
leukocyte 2
Gpr65 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2762 99.96 Very High Very High Very High
qutenza 2420 99.50 Very High Very High Very High
Hyperalgesia 1265 99.48 Very High Very High Very High
IPN 1541 99.40 Very High Very High Very High
ASIC 110 99.20 Very High Very High Very High
Thermal hyperalgesia 220 98.08 Very High Very High Very High
nociceptor 385 97.24 Very High Very High Very High
Kinase C 495 96.20 Very High Very High Very High
withdrawal 550 90.24 High High
Pain 771 89.92 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 2827 99.96 Very High Very High Very High
Hyperalgesia 1485 99.48 Very High Very High Very High
Inflammatory Pain 1541 99.40 Very High Very High Very High
Breast Cancer 46 98.68 Very High Very High Very High
Bordatella Infection 110 97.92 Very High Very High Very High
Pressure And Volume Under Development 1155 94.72 High High
Apoptosis 56 94.40 High High
Nociception 495 90.36 High High
Pain 881 89.92 High High
Neuropathic Pain 56 78.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TDAG8-expressing neurons were increased in number in small- and large-diameter neuron populations.
Gene_expression (expressing) of TDAG8 in neuron
1) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.07 Pain Relevance 0.06
At 24 hours after carrageenan injection, GPR4, TDAG8 and G2A expression increased (1.4~2.2-fold for GPR4, 1.4~2.1-fold for G2A, and 1.4~1.9-fold for TDAG8; Fig. 2B).
Gene_expression (expression) of TDAG8
2) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.67 Pain Relevance 0.35
Of the neurons labeled with PERI, 33 ± 4% of IB4-positive neurons expressed TDAG8 on the ipsilateral DRG as compared with 21 ± 4% on the contralateral DRG at 24 hours after CFA injection.
Gene_expression (expressed) of TDAG8 in neurons
3) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.14 Pain Relevance 0.16
At 24 hours after CFA injection, only TDAG8 expression was increased greatly (2.5~4.3-fold), but the level was reduced at 72 hours (1.2~1.6-fold) (Fig. 2C).
Gene_expression (expression) of TDAG8
4) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.61 Pain Relevance 0.33
At 24 hours after CFA injection, 27 ± 2% of total neurons expressed TDAG8 in the contralateral DRG, which was consistent with results for untreated controls found in a previous study [28], whereas the number was increased to 38 ± 2% on the ipsilateral DRG (Fig. 4A, B, Table 1).
Gene_expression (expressed) of TDAG8 in neurons
5) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.18 Pain Relevance 0.20
In N52-positive populations, 17 ± 2% showed TDAG8 expression on the ipsilateral DRG and 10 ± 3% on the contralateral DRG (Fig. 4A, B).
Gene_expression (expression) of TDAG8
6) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.12 Pain Relevance 0.12
GPR4, G2A, and TDAG8 transcripts were increased in levels 24 hours after carrageenan injection, but only TDAG8 expression was increased after CFA injection.
Gene_expression (expression) of TDAG8
7) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 1.00 Pain Relevance 0.94
The large increase of [Ca2+]i is unlikely directly induced by TDAG8 because cells expressing TDAG8 alone did not show elevated [Ca2+]i levels but, rather, accumulated intracellular cAMP levels.
Gene_expression (expressing) of TDAG8
8) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.28 Pain Relevance 0.85
Given that the number of neurons expressing both TDAG8 and TRPV1 genes was increased as well and that TDAG8 activation sensitized TRPV1 responses to capsaicin, TDAG8 is likely involved in long-term chronic inflammatory pain by sensitizing TRPV1 function.
Gene_expression (expressing) of TDAG8 in neurons associated with qutenza and ipn
9) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.87 Pain Relevance 0.84
Accordingly, TDAG8-expressing neurons were increased in number in both IB4-positive and -negative populations after CFA injection.


Gene_expression (expressing) of TDAG8 in IB4
10) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.16 Pain Relevance 0.15
Given that IB4-positive neurons had more TDAG8 expression than IB4-negative neurons after CFA-injection, the enhanced sensitivity of IB4-positive neurons to capsaicin may be due to increased TDAG8 expression.
Gene_expression (expression) of TDAG8 in neurons associated with qutenza
11) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.12 Pain Relevance 0.70
In small-diameter neurons, TDAG8-expressing neurons were increased in number in both IB4-positive and -negative nociceptors.
Gene_expression (expressing) of TDAG8 in IB4 associated with nociceptor
12) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.60 Pain Relevance 0.81
TDAG8 expression was further examined in peptidergic (IB4-negative) and non-peptidergic (IB4-positive) sub-populations.
Spec (examined) Gene_expression (expression) of TDAG8 in IB4
13) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.09 Pain Relevance 0.13
To further determine whether the increased TDAG8 expression was due to an increased number of DRG neurons, we used in situ hybridization to examine L4-5 DRG 24 hours after CFA injection.
Gene_expression (expression) of TDAG8 in neurons
14) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.36 Pain Relevance 0.39
After inflammation, an increased number of PERI- and N52-positive neurons began to express TDAG8 (Table 3), but mainly the N52-positive population showed an increase in number of neurons expressing TRPV1 (from 12 ± 3% to 23 ± 6%, Table 3).
Gene_expression (express) of TDAG8 in neurons associated with inflammation
15) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.36 Pain Relevance 0.34
Increased mRNA levels were due to the increased number of neurons expressing TDAG8.
Gene_expression (expressing) of TDAG8 in neurons
16) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.84 Pain Relevance 0.81
The plasticity of A-fiber neurons is an important mechanism that causes hyperalgesia following inflammation, therefore, increased TDAG8 expression in A-fiber could be involved in mechanical and thermal hyperalgesia by regulating TRPV1 function.
Gene_expression (expression) of TDAG8 in neurons associated with hyperalgesia, inflammation and thermal hyperalgesia
17) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.56 Pain Relevance 0.69
Although TDAG8 expression is required for the production of cAMP in immune cells, mice lacking TDAG8 have normal immune cell development [43,44].
Gene_expression (expression) of TDAG8 in immune cell
18) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.87 Pain Relevance 0.60
Of PERI-positive neurons, 24 ± 3% expressed TDAG8 on the ipsilateral DRG and 20 ± 2% on the contralateral DRG (Fig. 4A, B).
Gene_expression (expressed) of TDAG8 in neurons
19) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.11 Pain Relevance 0.06
We first examined proton signaling in HEK293T cells transfected with TDAG8.
Gene_expression (transfected) of TDAG8
20) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.23 Pain Relevance 0.14

General Comments

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