INT233461

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.37
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar6) plasma membrane (Lpar6) molecular_function (Lpar6)
biological_process (Lpar6) signal transducer activity (Lpar6)
Anatomy Link Frequency
macrophages 2
Lpar6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 18 97.08 Very High Very High Very High
Inflammatory stimuli 12 90.76 High High
Inflammation 33 79.72 Quite High
antagonist 6 73.12 Quite High
agonist 18 67.48 Quite High
adenocard 9 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 3 99.92 Very High Very High Very High
INFLAMMATION 63 96.68 Very High Very High Very High
Hypoxia 3 33.36 Quite Low
Injury 3 30.36 Quite Low
Stress 3 29.68 Quite Low
Mycobacterial Infection 9 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Demyelinating Disease 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We recently validated the LPS-mediated repression of P2ry5 mRNA expression in BMM by real time PCR [2].
Transcription (expression) of P2ry5 associated with repression
1) Confidence 0.48 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.10 Pain Relevance 0
This laboratory previously reported that P2ry5 mRNA expression was dramatically repressed by LPS in human and mouse macrophages [2], a finding supported by micro-array data presented here.
Transcription (expression) of P2ry5 in macrophages
2) Confidence 0.36 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.10 Pain Relevance 0.15
Several members of the P2RY family had striking expression patterns in macrophages; P2ry6 mRNA was essentially expressed in a macrophage-specific fashion, whilst P2ry1 and P2ry5 mRNA levels were strongly down-regulated by LPS.
Transcription (levels) of P2ry5 in macrophage
3) Confidence 0.36 Published 2008 Journal Immunome Res Section Abstract Doc Link PMC2394514 Disease Relevance 0.17 Pain Relevance 0.11

General Comments

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