INT233463

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.49
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr84) plasma membrane (Gpr84) signal transducer activity (Gpr84)
Anatomy Link Frequency
macrophages 2
Gpr84 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 2 86.00 High High
Central nervous system 2 79.32 Quite High
chemokine 4 53.68 Quite High
Inflammation 22 19.12 Low Low
agonist 12 9.88 Low Low
Inflammatory response 12 7.92 Low Low
Inflammatory stimuli 8 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 2 97.88 Very High Very High Very High
Repression 2 95.08 Very High Very High Very High
Multiple Sclerosis 2 90.08 High High
Demyelinating Disease 2 86.00 High High
Apoptosis 2 63.24 Quite High
Mycobacterial Infection 6 56.16 Quite High
INFLAMMATION 42 19.12 Low Low
Necrosis 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This up-regulation is consistent with elevated Gpr84 expression in microglia and tissue macrophages in an endotoxin shock model [43].
Positive_regulation (elevated) of Gene_expression (expression) of Gpr84 in macrophages associated with shock
1) Confidence 0.61 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.39 Pain Relevance 0.11
Figure 3 highlights two examples of regulated GPCR expression: mRNA expression of Gpr84 was induced 10-fold by LPS (6 h) in BMM and 48-fold by LPS (7 h) in TEPM (Figure 3a), whilst P2ry1 was repressed 7-fold by LPS (6 h) in BMM and 18-fold by LPS (7 h) in TEPM (Figure 3b).
Positive_regulation (induced) of Gene_expression (expression) of Gpr84
2) Confidence 0.44 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.10 Pain Relevance 0

General Comments

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