INT233464

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.81
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (S1pr1) plasma membrane (S1pr1) signal transducer activity (S1pr1)
Anatomy Link Frequency
lymphoid tissues 2
S1pr1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 260 97.20 Very High Very High Very High
Inflammation 183 95.20 Very High Very High Very High
Arthritis 256 94.68 High High
agonist 14 78.48 Quite High
Inflammatory response 18 76.52 Quite High
metalloproteinase 4 27.04 Quite Low
chemokine 10 22.40 Low Low
cytokine 61 21.92 Low Low
Central nervous system 5 7.60 Low Low
methotrexate 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 181 100.00 Very High Very High Very High
Rheumatoid Arthritis 260 97.20 Very High Very High Very High
Arthritis 248 95.20 Very High Very High Very High
INFLAMMATION 89 76.12 Quite High
Mycobacterial Infection 3 66.48 Quite High
Carcinoma 4 65.20 Quite High
Necrosis 22 63.96 Quite High
Cancer 50 63.60 Quite High
Adhesions 5 22.80 Low Low
Disease 13 10.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, inhibiting the formation of S1P either by targeting SphK, or by inhibiting the binding of S1P to S1PR1/S1PR2 is likely to result in a reduced egress of activated T-cell and B-cell from lymphoid tissues and presumably fewer activated lymphocytes making their way into the synovium.
S1P Binding (formation) of in lymphoid tissues
1) Confidence 0.28 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.34 Pain Relevance 0.15
Additionally, it was shown that the secreted form of S1P also regulated cell survival and apoptosis by its capacity to bind to and activate 5 specific G protein-coupled receptors, S1P1-S1P15 [35].
S1P Binding (bind) of associated with apoptosis
2) Confidence 0.28 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.36 Pain Relevance 0.07
Thus, inhibiting the formation of S1P either by targeting SphK, or by inhibiting the binding of S1P to S1PR1/S1PR2 is likely to result in a reduced egress of activated T-cell and B-cell from lymphoid tissues and presumably fewer activated lymphocytes making their way into the synovium.
S1P Binding (binding) of in lymphoid tissues
3) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.40 Pain Relevance 0.18
What is the current evidence that altering the activity of S1P would provide significant and beneficial effects by restricting some of the pathophysiologic events that contribute to inflammatory arthritis?
S1P Binding (activity) of associated with inflammation and arthritis
4) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.50 Pain Relevance 0.18
Edg5 is one of eight members of the endothelial differentiation gene (EDG) family of GPCRs that recognize LPA and S1P [34].
S1P Binding (recognize) of
5) Confidence 0.16 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.20 Pain Relevance 0.08

General Comments

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