INT233466

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.52
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry6) plasma membrane (P2ry6) signal transducer activity (P2ry6)
Anatomy Link Frequency
microglia 7
dendritic cells 4
osteoclasts 1
P2ry6 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 12 94.28 High High
Inflammatory response 36 94.16 High High
agonist 36 88.64 High High
Inflammatory stimuli 24 85.08 High High
Inflammation 66 5.00 Very Low Very Low Very Low
adenocard 18 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Analgesic 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 126 93.76 High High
Hypoxia 6 87.20 High High
Injury 6 84.20 Quite High
Stress 6 83.52 Quite High
Repression 6 5.96 Low Low
Mycobacterial Infection 18 5.00 Very Low Very Low Very Low
Necrosis 12 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low
Demyelinating Disease 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In microglia, P2ry6 mRNA expression was up-regulated in response to neuronal damage and UDP promoted phagocytosis by microglia, thus implying a role for P2RY6 in the clearance of damaged or dead neuronal cells [23].
Positive_regulation (regulated) of Transcription (expression) of P2ry6 in microglia
1) Confidence 0.40 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.34 Pain Relevance 0.18
In microglia, P2ry6 mRNA expression was up-regulated in response to neuronal damage and UDP promoted phagocytosis by microglia, thus implying a role for P2RY6 in the clearance of damaged or dead neuronal cells [23].
Positive_regulation (up) of Transcription (expression) of P2ry6 in microglia
2) Confidence 0.40 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.34 Pain Relevance 0.18
In microglia, P2ry6 mRNA expression was up-regulated in response to neuronal damage and UDP promoted phagocytosis by microglia, thus implying a role for P2RY6 in the clearance of damaged or dead neuronal cells [23].
Positive_regulation (-) of Transcription (expression) of P2ry6 in microglia
3) Confidence 0.40 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.34 Pain Relevance 0.18
P2ry6 mRNA levels were greatly elevated in BMM, TEPM, RAW264 cells, microglia, osteoclasts and dendritic cells, compared to all other cell types (Figure 1b).
Positive_regulation (elevated) of Transcription (levels) of P2ry6 in dendritic cells
4) Confidence 0.40 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.50 Pain Relevance 0.18
P2ry6 mRNA levels were greatly elevated in BMM, TEPM, RAW264 cells, microglia, osteoclasts and dendritic cells, compared to all other cell types (Figure 1b).
Positive_regulation (elevated) of in microglia Transcription (levels) of P2ry6 in dendritic cells
5) Confidence 0.13 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.50 Pain Relevance 0.18
P2ry6 mRNA levels were greatly elevated in BMM, TEPM, RAW264 cells, microglia, osteoclasts and dendritic cells, compared to all other cell types (Figure 1b).
Positive_regulation (elevated) of in osteoclasts Transcription (levels) of P2ry6 in dendritic cells
6) Confidence 0.13 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.50 Pain Relevance 0.18

General Comments

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