INT233467

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.77
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Itm2b) plasma membrane (Itm2b) nucleus (Itm2b)
Anatomy Link Frequency
macrophage 1
Itm2b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 6 95.68 Very High Very High Very High
Inflammation 12 59.08 Quite High
chemokine 2 45.24 Quite Low
agonist 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dementia 45 99.92 Very High Very High Very High
Targeted Disruption 27 99.76 Very High Very High Very High
INFLAMMATION 22 95.68 Very High Very High Very High
Disease 10 94.76 High High
Mycobacterial Infection 3 94.28 High High
Adhesions 1 80.56 Quite High
Neurodegenerative Disease 5 75.76 Quite High
Ataxia 3 70.00 Quite High
Amyloidosis 4 68.56 Quite High
Gliosis 1 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we have generated a genetically faithful model of FDD by introducing the pathogenic human mutation in the mouse BRI2 gene by a knock-in technology.
Regulation (introducing) of BRI2 gene associated with targeted disruption and dementia
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 1.44 Pain Relevance 0
The striking up-regulation of Fzd1 in BMM (17-fold at 6 h LPS) implies that this FZD family member shares similar functions in regulating macrophage inflammatory responses.
Regulation (regulation) of BMM in macrophage associated with inflammatory response
2) Confidence 0.01 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.33 Pain Relevance 0.08

General Comments

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