INT233469

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.02
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry6) plasma membrane (P2ry6) signal transducer activity (P2ry6)
Anatomy Link Frequency
microglia 2
macrophage 1
dendritic cells 1
osteoclasts 1
P2ry6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 20 94.28 High High
antagonist 10 94.28 High High
Inflammatory response 30 94.16 High High
agonist 30 88.64 High High
Inflammation 55 83.24 Quite High
adenocard 15 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Analgesic 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 105 93.92 High High
Hypoxia 5 87.20 High High
Injury 5 84.20 Quite High
Stress 5 83.52 Quite High
Repression 5 5.96 Low Low
Mycobacterial Infection 15 5.00 Very Low Very Low Very Low
Necrosis 10 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low
Demyelinating Disease 5 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P2ry6 mRNA levels were greatly elevated in BMM, TEPM, RAW264 cells, microglia, osteoclasts and dendritic cells, compared to all other cell types (Figure 1b).
Transcription (levels) of P2ry6 in dendritic cells
1) Confidence 0.45 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.50 Pain Relevance 0.15
In microglia, P2ry6 mRNA expression was up-regulated in response to neuronal damage and UDP promoted phagocytosis by microglia, thus implying a role for P2RY6 in the clearance of damaged or dead neuronal cells [23].
Transcription (expression) of P2ry6 in microglia
2) Confidence 0.45 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.34 Pain Relevance 0.18
Several members of the P2RY family had striking expression patterns in macrophages; P2ry6 mRNA was essentially expressed in a macrophage-specific fashion, whilst P2ry1 and P2ry5 mRNA levels were strongly down-regulated by LPS.
Transcription (expressed) of P2ry6 in macrophage
3) Confidence 0.45 Published 2008 Journal Immunome Res Section Abstract Doc Link PMC2394514 Disease Relevance 0.18 Pain Relevance 0.09
P2ry6 mRNA levels were greatly elevated in BMM, TEPM, RAW264 cells, microglia, osteoclasts and dendritic cells, compared to all other cell types (Figure 1b).
Transcription (levels) of P2ry6 in osteoclasts
4) Confidence 0.15 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.50 Pain Relevance 0.15
P2ry6 mRNA levels were greatly elevated in BMM, TEPM, RAW264 cells, microglia, osteoclasts and dendritic cells, compared to all other cell types (Figure 1b).
Transcription (levels) of P2ry6 in microglia
5) Confidence 0.15 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.50 Pain Relevance 0.15

General Comments

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