INT233471

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 3.01
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr84) plasma membrane (Gpr84) signal transducer activity (Gpr84)
Anatomy Link Frequency
macrophages 4
microglia 3
granulocytes 1
Gpr84 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 22 100.00 Very High Very High Very High
Inflammation 121 98.00 Very High Very High Very High
Multiple sclerosis 11 97.64 Very High Very High Very High
Central nervous system 11 88.92 High High
agonist 66 86.48 High High
Inflammatory response 66 84.52 Quite High
antagonist 22 5.84 Low Low
Inflammatory stimuli 44 5.00 Very Low Very Low Very Low
adenocard 33 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 11 99.68 Very High Very High Very High
Shock 11 98.88 Very High Very High Very High
INFLAMMATION 231 98.00 Very High Very High Very High
Demyelinating Disease 11 97.64 Very High Very High Very High
Repression 11 95.08 Very High Very High Very High
Apoptosis 11 72.84 Quite High
Mycobacterial Infection 33 65.76 Quite High
Necrosis 22 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Hypoxia 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This up-regulation is consistent with elevated Gpr84 expression in microglia and tissue macrophages in an endotoxin shock model [43].
Gene_expression (expression) of Gpr84 in macrophages associated with shock
1) Confidence 0.68 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.39 Pain Relevance 0.11
Microglia also expressed high levels of Gpr84 in the experimental autoimmune encephalomyelitis model of multiple sclerosis [43].
Gene_expression (expressed) of Gpr84 in Microglia associated with multiple sclerosis
2) Confidence 0.68 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.41 Pain Relevance 0.12
Gpr84 expression was also largely restricted to macrophage populations and granulocytes (Figure 1c).


Gene_expression (expression) of Gpr84 in granulocytes
3) Confidence 0.68 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.16 Pain Relevance 0.08
Figure 3 highlights two examples of regulated GPCR expression: mRNA expression of Gpr84 was induced 10-fold by LPS (6 h) in BMM and 48-fold by LPS (7 h) in TEPM (Figure 3a), whilst P2ry1 was repressed 7-fold by LPS (6 h) in BMM and 18-fold by LPS (7 h) in TEPM (Figure 3b).
Gene_expression (expression) of Gpr84
4) Confidence 0.59 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.10 Pain Relevance 0
Nonetheless, given the highly restricted expression pattern of Gpr84 mRNA, antibodies against this receptor may provide useful tools for tracking macrophage populations in vivo.
Gene_expression (expression) of Gpr84 in macrophage
5) Confidence 0.59 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.32 Pain Relevance 0.15
Examples of these include Ccr2, Gpr84 and Fprl1 that were selectively enriched in BMM as compared to TEPM and RAW264, whilst Gpr68 was enriched in both TEPM and RAW264 but not BMM.
Gene_expression (enriched) of Gpr84
6) Confidence 0.59 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.12 Pain Relevance 0.06
Gpr84 is an orphan GPCR that was strikingly restricted to BMM and microglia in an unstimulated state (Table 2, Figure 1c) and was strongly up-regulated by LPS in both BMM and TEPM (Figure 3a, Table 3).
Gene_expression (restricted) of Gpr84 in microglia
7) Confidence 0.59 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.42 Pain Relevance 0.08
Gpr84 is an orphan GPCR that was strikingly restricted to BMM and microglia in an unstimulated state (Table 2, Figure 1c) and was strongly up-regulated by LPS in both BMM and TEPM (Figure 3a, Table 3).
Gene_expression (was) of Gpr84 in microglia
8) Confidence 0.59 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.44 Pain Relevance 0.08
As with Gpr84, mRNA for several other GPCRs, particularly chemokine receptors, were differentially expressed between various unstimulated macrophage populations.
Gene_expression (expressed) of Gpr84 in macrophage associated with chemokine
9) Confidence 0.46 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.32 Pain Relevance 0.18
Those GPCRs that were highly expressed by BMM, but not TEPM, included Ebi2, Calcrl, Ccr2 and 5, Cxcr3, Cx3cr1 and Gpr84, whilst TEPM expressed much higher levels of Cxcr4, Gpr35, P2ry1, Ccr1, Cd97, Ccrl2 and Gprc5b (Table 2).
Neg (not) Gene_expression (expressed) of Gpr84
10) Confidence 0.23 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.19 Pain Relevance 0.10
Other GPCRs that had a relatively restricted expression pattern and were strongly expressed by macrophages include Edg5, Gpr85 and Gpr84 (Table 2, Figure 1a and 1c, Additional file 2b).
Gene_expression (expressed) of Gpr84 in macrophages
11) Confidence 0.20 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.14 Pain Relevance 0.09

General Comments

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