INT233475

Context Info Confidence 0.66 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 9 Disease Relevance 1.78 Pain Relevance 0.39

signal transduction (Gpr85) plasma membrane (Gpr85) signal transducer activity (Gpr85)

Anatomy Link Frequency macrophages 5 neuronal 2 leukocyte 1 central nervous system 1 Gpr85 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 9 99.68 agonist 54 86.48 Inflammatory response 54 84.52 Multiple sclerosis 9 52.64 Inflammation 99 25.52 Inflammatory stimuli 36 21.20 chemokine 18 20.32 antagonist 18 5.84 adenocard 27 5.00 cytokine 9 5.00

Disease Link Frequency Relevance Heat Apoptosis 9 92.76 Mycobacterial Infection 27 85.68 INFLAMMATION 189 84.12 Shock 9 62.40 Multiple Sclerosis 9 56.72 Demyelinating Disease 9 52.64 Disease 9 25.84 Necrosis 18 5.00 Cancer 18 5.00 Hypoxia 9 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The co-regulated expression of receptors such as Gpr85 in neural tissues and leukocyte populations may provide a mechanism for the neuro-immune cross-talk that has been observed in several studies [41,42].

Gene_expression (expression) of Gpr85 in leukocyte

1) Confidence 0.66 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.39 Pain Relevance 0.07

Whilst the expression of Gpr85 in the central nervous system was previously reported [38-40], a function has yet to be identified.

Gene_expression (expression) of Gpr85 in central nervous system associated with central nervous system

2) Confidence 0.66 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.24 Pain Relevance 0.05

For example, Gpr85 was highly expressed in several macrophage populations and was further up-regulated by LPS, but was also expressed in several regions of the brain (Figure 1a).

Gene_expression (expressed) of Gpr85 in macrophage

3) Confidence 0.66 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0 Pain Relevance 0

Expression of the SREB (super conserved receptor expressed in brain) family member Gpr85 (Sreb2) was restricted to macrophages and neuronal tissues (Figure 1a).

Gene_expression (Expression) of Gpr85 in macrophages

4) Confidence 0.66 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.26 Pain Relevance 0.05

For example, Gpr85 was highly expressed in several macrophage populations and was further up-regulated by LPS, but was also expressed in several regions of the brain (Figure 1a).

Gene_expression (expressed) of Gpr85 in macrophage

5) Confidence 0.66 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0 Pain Relevance 0

Expression of the SREB (super conserved receptor expressed in brain) family member Gpr85 (Sreb2) was restricted to macrophages and neuronal tissues (Figure 1a).

Gene_expression (expressed) of Gpr85 in macrophages

6) Confidence 0.58 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.25 Pain Relevance 0.05

Other GPCRs that had a relatively restricted expression pattern and were strongly expressed by macrophages include Edg5, Gpr85 and Gpr84 (Table 2, Figure 1a and 1c, Additional file 2b).

Gene_expression (expressed) of Gpr85 in macrophages

7) Confidence 0.23 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.14 Pain Relevance 0.09

Expression of the SREB (super conserved receptor expressed in brain) family member Gpr85 (Sreb2) was restricted to macrophages and neuronal tissues (Figure 1a).

Gene_expression (Expression) of Gpr85 in neuronal

8) Confidence 0.23 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.26 Pain Relevance 0.05

Expression of the SREB (super conserved receptor expressed in brain) family member Gpr85 (Sreb2) was restricted to macrophages and neuronal tissues (Figure 1a).

Gene_expression (expressed) of Gpr85 in neuronal

9) Confidence 0.20 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.25 Pain Relevance 0.05

General Comments

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