INT233475

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Context Info
Confidence 0.66
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 1.78
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr85) plasma membrane (Gpr85) signal transducer activity (Gpr85)
Anatomy Link Frequency
macrophages 5
neuronal 2
leukocyte 1
central nervous system 1
Gpr85 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 9 99.68 Very High Very High Very High
agonist 54 86.48 High High
Inflammatory response 54 84.52 Quite High
Multiple sclerosis 9 52.64 Quite High
Inflammation 99 25.52 Quite Low
Inflammatory stimuli 36 21.20 Low Low
chemokine 18 20.32 Low Low
antagonist 18 5.84 Low Low
adenocard 27 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 9 92.76 High High
Mycobacterial Infection 27 85.68 High High
INFLAMMATION 189 84.12 Quite High
Shock 9 62.40 Quite High
Multiple Sclerosis 9 56.72 Quite High
Demyelinating Disease 9 52.64 Quite High
Disease 9 25.84 Quite Low
Necrosis 18 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low
Hypoxia 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The co-regulated expression of receptors such as Gpr85 in neural tissues and leukocyte populations may provide a mechanism for the neuro-immune cross-talk that has been observed in several studies [41,42].
Gene_expression (expression) of Gpr85 in leukocyte
1) Confidence 0.66 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.39 Pain Relevance 0.07
Whilst the expression of Gpr85 in the central nervous system was previously reported [38-40], a function has yet to be identified.
Gene_expression (expression) of Gpr85 in central nervous system associated with central nervous system
2) Confidence 0.66 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.24 Pain Relevance 0.05
For example, Gpr85 was highly expressed in several macrophage populations and was further up-regulated by LPS, but was also expressed in several regions of the brain (Figure 1a).
Gene_expression (expressed) of Gpr85 in macrophage
3) Confidence 0.66 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0 Pain Relevance 0
Expression of the SREB (super conserved receptor expressed in brain) family member Gpr85 (Sreb2) was restricted to macrophages and neuronal tissues (Figure 1a).
Gene_expression (Expression) of Gpr85 in macrophages
4) Confidence 0.66 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.26 Pain Relevance 0.05
For example, Gpr85 was highly expressed in several macrophage populations and was further up-regulated by LPS, but was also expressed in several regions of the brain (Figure 1a).
Gene_expression (expressed) of Gpr85 in macrophage
5) Confidence 0.66 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0 Pain Relevance 0
Expression of the SREB (super conserved receptor expressed in brain) family member Gpr85 (Sreb2) was restricted to macrophages and neuronal tissues (Figure 1a).
Gene_expression (expressed) of Gpr85 in macrophages
6) Confidence 0.58 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.25 Pain Relevance 0.05
Other GPCRs that had a relatively restricted expression pattern and were strongly expressed by macrophages include Edg5, Gpr85 and Gpr84 (Table 2, Figure 1a and 1c, Additional file 2b).
Gene_expression (expressed) of Gpr85 in macrophages
7) Confidence 0.23 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.14 Pain Relevance 0.09
Expression of the SREB (super conserved receptor expressed in brain) family member Gpr85 (Sreb2) was restricted to macrophages and neuronal tissues (Figure 1a).
Gene_expression (Expression) of Gpr85 in neuronal
8) Confidence 0.23 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.26 Pain Relevance 0.05
Expression of the SREB (super conserved receptor expressed in brain) family member Gpr85 (Sreb2) was restricted to macrophages and neuronal tissues (Figure 1a).
Gene_expression (expressed) of Gpr85 in neuronal
9) Confidence 0.20 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.25 Pain Relevance 0.05

General Comments

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