INT233479

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.89
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Gprc5b) signal transducer activity (Gprc5b) signal transduction (Gprc5b)
nucleolus (Gprc5b) nucleus (Gprc5b) plasma membrane (Gprc5b)
Gprc5b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 55 93.84 High High
chemokine 10 93.68 High High
Multiple sclerosis 5 51.52 Quite High
Inflammatory stimuli 20 37.36 Quite Low
Central nervous system 5 22.12 Low Low
Inflammatory response 30 5.00 Very Low Very Low Very Low
agonist 30 5.00 Very Low Very Low Very Low
adenocard 15 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 105 93.84 High High
Repression 5 68.32 Quite High
Demyelinating Disease 5 51.52 Quite High
Multiple Sclerosis 5 50.40 Quite High
Adhesions 5 46.16 Quite Low
Shock 5 46.12 Quite Low
Mycobacterial Infection 15 19.04 Low Low
Stress 5 10.08 Low Low
Injury 5 8.72 Low Low
Apoptosis 5 6.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As an example, figure 2a and 2b demonstrate the selective expression of Calcrl and Gprc5b in BMM and TEPM, respectively.
Gene_expression (expression) of Gprc5b
1) Confidence 0.64 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.17 Pain Relevance 0.09
Those GPCRs that were highly expressed by BMM, but not TEPM, included Ebi2, Calcrl, Ccr2 and 5, Cxcr3, Cx3cr1 and Gpr84, whilst TEPM expressed much higher levels of Cxcr4, Gpr35, P2ry1, Ccr1, Cd97, Ccrl2 and Gprc5b (Table 2).
Gene_expression (expressed) of Gprc5b
2) Confidence 0.56 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.19 Pain Relevance 0.09
For example, the thrombin-related receptor, Ebi2 [46], was strongly expressed in BMM but not TEPM, whilst Gprc5b was enriched in TEPM but not BMM.
Neg (not) Gene_expression (expressed) of Gprc5b
3) Confidence 0.56 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.28 Pain Relevance 0.19
Gpr18, P2ry2, P2ry12 and Adrb2 were all strongly regulated by LPS in BMM, but not TEPM (Table 3, 4), whilst LPS regulated Gprc5b expression in TEPM, but not BMM (Table 4).
Gene_expression (expression) of Gprc5b
4) Confidence 0.50 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.07 Pain Relevance 0
Those GPCRs that were highly expressed by BMM, but not TEPM, included Ebi2, Calcrl, Ccr2 and 5, Cxcr3, Cx3cr1 and Gpr84, whilst TEPM expressed much higher levels of Cxcr4, Gpr35, P2ry1, Ccr1, Cd97, Ccrl2 and Gprc5b (Table 2).
Gene_expression (levels) of Gprc5b
5) Confidence 0.44 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.18 Pain Relevance 0.09

General Comments

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