INT233480

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.46
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (S1pr2) plasma membrane (S1pr2) signal transducer activity (S1pr2)
Anatomy Link Frequency
macrophage 3
S1pr2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 33 86.48 High High
Inflammatory response 19 84.52 Quite High
Central nervous system 3 77.44 Quite High
Inflammation 34 42.64 Quite Low
Multiple sclerosis 5 18.32 Low Low
antagonist 21 5.84 Low Low
Inflammatory stimuli 12 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
adenocard 9 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 18 96.80 Very High Very High Very High
Mycobacterial Infection 12 89.72 High High
INFLAMMATION 65 84.12 Quite High
Cancer 30 54.20 Quite High
Shock 4 28.08 Quite Low
Multiple Sclerosis 3 22.40 Low Low
Demyelinating Disease 7 18.32 Low Low
Disease 10 8.32 Low Low
Ovarian Cancer 16 5.00 Very Low Very Low Very Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EDG1 was implicated in this response, but given the high expression of Edg5 reported here, this receptor may also be involved in macrophage responses to S1P.
Gene_expression (expression) of Edg5 in macrophage
1) Confidence 0.50 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.27 Pain Relevance 0.04
Edg5, P2ry2 and 6) that have not previously been reported to have a macrophage-restricted expression pattern (Table 2).
Gene_expression (expression) of Edg5 in macrophage
2) Confidence 0.44 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0 Pain Relevance 0
Other GPCRs that had a relatively restricted expression pattern and were strongly expressed by macrophages include Edg5, Gpr85 and Gpr84 (Table 2, Figure 1a and 1c, Additional file 2b).
Gene_expression (expressed) of Edg5 in macrophages
3) Confidence 0.39 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.14 Pain Relevance 0.09
In addition, five S1P-specific receptors, S1P1, S1P2, S1P3, S1P4 and S1P5, belong to this gene cluster.
Gene_expression (belong) of S1P2
4) Confidence 0.29 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox