INT233482

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.76
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry2) mitochondrion (P2ry2) plasma membrane (P2ry2)
lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
monocytes 6
P2ry2 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 44 95.16 Very High Very High Very High
agonist 22 92.84 High High
Inflammatory response 18 85.24 High High
Calcitonin gene-related peptide 1 71.76 Quite High
Nerve growth factor 6 70.24 Quite High
antagonist 9 50.00 Quite Low
Mechanotransduction 3 50.00 Quite Low
low threshold mechanoreceptor 4 11.40 Low Low
Inflammation 38 5.00 Very Low Very Low Very Low
c fibre 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 34 99.92 Very High Very High Very High
INFLAMMATION 68 84.84 Quite High
Nociception 6 60.76 Quite High
Ganglion Cysts 13 5.00 Very Low Very Low Very Low
Mycobacterial Infection 9 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Demyelinating Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of a role for P2Y ATP receptors in macrophage function, and consistent with our data, P2ry1 and P2ry2 mRNAs were expressed at high levels in macrophages and LPS-stimulated monocytes [31].
Positive_regulation (macrophages) of Gene_expression (expressed) of P2ry2 in monocytes
1) Confidence 0.43 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.08 Pain Relevance 0.13
In support of a role for P2Y ATP receptors in macrophage function, and consistent with our data, P2ry1 and P2ry2 mRNAs were expressed at high levels in macrophages and LPS-stimulated monocytes [31].
Positive_regulation (stimulated) of Gene_expression (expressed) of P2ry2 in monocytes
2) Confidence 0.43 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.14 Pain Relevance 0.16
In support of a role for P2Y ATP receptors in macrophage function, and consistent with our data, P2ry1 and P2ry2 mRNAs were expressed at high levels in macrophages and LPS-stimulated monocytes [31].
Positive_regulation (levels) of Gene_expression (expressed) of P2ry2 in monocytes
3) Confidence 0.43 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.08 Pain Relevance 0.13
The effect of UTP is mediated by metabotropic P2Y2 receptors
Positive_regulation (mediated) of Gene_expression (receptors) of P2Y2
4) Confidence 0.24 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.46 Pain Relevance 0.50

General Comments

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