INT233484

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.95
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry1) mitochondrion (P2ry1) plasma membrane (P2ry1)
signal transducer activity (P2ry1)
Anatomy Link Frequency
monocytes 6
astrocyte 2
P2ry1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 23 93.24 High High
Inflammatory response 18 85.64 High High
antagonist 6 50.40 Quite High
imagery 15 43.72 Quite Low
ischemia 6 35.96 Quite Low
Inflammation 33 5.00 Very Low Very Low Very Low
Inflammatory stimuli 12 5.00 Very Low Very Low Very Low
adenocard 9 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Hemorrhage 24 89.08 High High
INFLAMMATION 63 85.24 High High
Necrosis 16 84.68 Quite High
Pressure And Volume Under Development 50 84.16 Quite High
Infarction 10 64.96 Quite High
Thrombosis 4 42.60 Quite Low
Targeted Disruption 4 34.08 Quite Low
Mycobacterial Infection 9 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low
Hypoxia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of a role for P2Y ATP receptors in macrophage function, and consistent with our data, P2ry1 and P2ry2 mRNAs were expressed at high levels in macrophages and LPS-stimulated monocytes [31].
Positive_regulation (levels) of Gene_expression (expressed) of P2ry1 in monocytes
1) Confidence 0.43 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.09 Pain Relevance 0.16
In support of a role for P2Y ATP receptors in macrophage function, and consistent with our data, P2ry1 and P2ry2 mRNAs were expressed at high levels in macrophages and LPS-stimulated monocytes [31].
Positive_regulation (macrophages) of Gene_expression (expressed) of P2ry1 in monocytes
2) Confidence 0.43 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.09 Pain Relevance 0.16
In support of a role for P2Y ATP receptors in macrophage function, and consistent with our data, P2ry1 and P2ry2 mRNAs were expressed at high levels in macrophages and LPS-stimulated monocytes [31].
Positive_regulation (stimulated) of Gene_expression (expressed) of P2ry1 in monocytes
3) Confidence 0.43 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.14 Pain Relevance 0.18
We employed a two-fold strategy to test the in vivo impact of astrocyte mitochondrial metabolism on P2Y1R enhanced protection.
Positive_regulation (enhanced) of Gene_expression (protection) of P2Y1R in astrocyte
4) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.65 Pain Relevance 0

General Comments

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