INT233488

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Context Info
Confidence 0.71
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 1.67
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry14) plasma membrane (P2ry14) signal transducer activity (P2ry14)
Anatomy Link Frequency
DRG 3
leukocyte 1
neurons 1
P2ry14 (Mus musculus)
Pain Link Frequency Relevance Heat
MU agonist 10 96.80 Very High Very High Very High
nociceptor 85 96.36 Very High Very High Very High
Inflammation 102 93.76 High High
imagery 45 93.44 High High
agonist 102 90.52 High High
mu opioid receptor 15 90.16 High High
adenocard 21 86.08 High High
Neurotransmitter 15 85.40 High High
Eae 15 75.00 Quite High
Neuropeptide 10 73.92 Quite High
Disease Link Frequency Relevance Heat
Nociception 155 95.60 Very High Very High Very High
INFLAMMATION 122 93.76 High High
Injury 37 92.72 High High
Bordatella Infection 15 77.76 Quite High
Inflammatory Pain 12 75.00 Quite High
Targeted Disruption 10 60.48 Quite High
Repression 2 52.08 Quite High
Hyperalgesia 80 37.20 Quite Low
Pain 25 5.00 Very Low Very Low Very Low
Mycobacterial Infection 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As an illustration, figure 2c shows the immune-restricted expression of P2ry14.


Gene_expression (expression) of P2ry14
1) Confidence 0.71 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.05 Pain Relevance 0
Although P2Y12 immunoreactivity was restricted to small neurons, both P2Y13 and P2Y14 were detected in some larger neurons.
Gene_expression (detected) of P2Y14 in neurons
2) Confidence 0.62 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.14 Pain Relevance 0.22
Gpr65, Ccr1, Ccrl1, Cnr2 and P2ry14) that were highly expressed by multiple leukocyte populations.
Gene_expression (expressed) of P2ry14 in leukocyte
3) Confidence 0.55 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0 Pain Relevance 0
P2Y12 and P2Y13 are preferentially activated by ADP, whereas P2Y14 is selective for glycosylated UDP.
Gene_expression (selective) of P2Y14
4) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.06 Pain Relevance 0.25
Here, we demonstrate that P2Y12, P2Y13 and P2Y14 are all expressed in sensory neurons of the dorsal root ganglia (DRG) with neurochemical characteristics of nociceptors.
Gene_expression (expressed) of P2Y14 in dorsal root ganglia associated with nociceptor
5) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.30 Pain Relevance 0.45
P2Y14, a homologous Gi-coupled nucleotide receptor, is also expressed in DRG.
Gene_expression (expressed) of P2Y14 in DRG
6) Confidence 0.48 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2865444 Disease Relevance 0.63 Pain Relevance 0.19
Expression of mRNA for all three of the Gi-coupled P2Y receptors was identified in mouse lumbar DRG by real-time PCR, with relative levels of expression of P2Y12 ~P2Y14 > P2Y13 (Table 1).
Gene_expression (expression) of P2Y14 in DRG
7) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.49 Pain Relevance 0.47

General Comments

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