INT233493

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 59
Total Number 59
Disease Relevance 11.61
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccrl2) plasma membrane (Ccrl2) signal transducer activity (Ccrl2)
Anatomy Link Frequency
mast cell 8
spleen 3
macrophages 2
neutrophils 2
peritoneal macrophages 2
Ccrl2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 1809 100.00 Very High Very High Very High
Multiple sclerosis 58 99.96 Very High Very High Very High
Inflammation 499 99.80 Very High Very High Very High
cytokine 320 99.38 Very High Very High Very High
rheumatoid arthritis 52 98.52 Very High Very High Very High
Inflammatory response 197 97.96 Very High Very High Very High
anesthesia 53 92.32 High High
ischemia 9 91.72 High High
ketamine 52 91.36 High High
Bioavailability 52 63.16 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 58 99.96 Very High Very High Very High
INFLAMMATION 720 99.80 Very High Very High Very High
Anaphylaxis 1508 99.76 Very High Very High Very High
Multiple Sclerosis 58 99.20 Very High Very High Very High
Injury 72 98.96 Very High Very High Very High
Rheumatoid Arthritis 52 98.52 Very High Very High Very High
Edema 988 98.24 Very High Very High Very High
Disease 112 98.08 Very High Very High Very High
Overdose 52 93.28 High High
Cv Unclassified Under Development 9 91.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Those GPCRs that were highly expressed by BMM, but not TEPM, included Ebi2, Calcrl, Ccr2 and 5, Cxcr3, Cx3cr1 and Gpr84, whilst TEPM expressed much higher levels of Cxcr4, Gpr35, P2ry1, Ccr1, Cd97, Ccrl2 and Gprc5b (Table 2).
Gene_expression (expressed) of Ccrl2
1) Confidence 0.65 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.19 Pain Relevance 0.09
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Gene_expression (expressed) of Ccrl2
2) Confidence 0.65 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.18
Nevertheless, included in this set were GPCRs such as Emr1 (F4/80), C3aR, C5aR, Ccrl2 and Ccr2 that are known to be either macrophage-specific or highly expressed by macrophages [8-12], thus validating our approach.
Gene_expression (expressed) of Ccrl2 in F4/80
3) Confidence 0.65 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0 Pain Relevance 0
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Gene_expression (expressed) of Ccrl2
4) Confidence 0.56 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.16
Gpr109b/PUMA-G, Fpr1, Ccrl2 and Ednrb) ([12-16], Sweet et al, unpublished data), regulated expression of others has not been widely studied.
Gene_expression (expression) of Ccrl2
5) Confidence 0.56 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.08 Pain Relevance 0
Our data indicate that at some point before 24 h after activation by TLR ligands or proinflammatory cytokines, macrophages can concurrently express both chemerin receptors CMKLR1 and CCRL2.
Gene_expression (express) of CCRL2 in macrophages associated with cytokine
6) Confidence 0.56 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.10
Neither mouse nor human CCRL2, expressed on L1.2 transfectants, underwent ligand-induced internalization (Fig. 8 A).
Gene_expression (expressed) of CCRL2
7) Confidence 0.56 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.07
CCRL2 expression by stromal cells in the lung and heart may serve to maintain a reservoir of chemerin and to buffer tissue levels of the attractant in vivo in the same manner that erythrocyte-expressed atypical chemokine receptor DARC can serve as a buffer to maintain chemokine levels in the blood (14, 15).
Gene_expression (expression) of CCRL2 in reservoir associated with chemokine
8) Confidence 0.56 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.13
Thus, we hypothesize that CCRL2 (e.g. expressed by mast cells and activated macrophages) binds to chemerin in vivo and presents the cell-signaling carboxyl-terminal domain of the chemoattractant to CMKLR1+ cells such as macrophages, pDC, and NK cells (Fig. 9).
Gene_expression (expressed) of CCRL2 in NK cells
9) Confidence 0.56 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.17 Pain Relevance 0.07
Our findings expand the possible ligand space for atypical orphan receptors to include chemoattractants beyond the chemokine family and provide a potential link between CCRL2 expression and chemerin-dependent effects on inflammation that are mediated via the cell-signaling chemerin receptor CMKLR1.


Gene_expression (expression) of CCRL2 associated with chemokine and inflammation
10) Confidence 0.56 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.18 Pain Relevance 0.18
Those GPCRs that were highly expressed by BMM, but not TEPM, included Ebi2, Calcrl, Ccr2 and 5, Cxcr3, Cx3cr1 and Gpr84, whilst TEPM expressed much higher levels of Cxcr4, Gpr35, P2ry1, Ccr1, Cd97, Ccrl2 and Gprc5b (Table 2).
Gene_expression (levels) of Ccrl2
11) Confidence 0.50 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.18 Pain Relevance 0.09
mCMKLR1-HA, huCCRL2-HA, and mCCRL2-HA L1.2 transfectants were incubated for 15 min with 100 nM serum form chemerin at the indicated temperature in cell culture media.
Gene_expression (transfectants) of huCCRL2-HA
12) Confidence 0.49 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
mCMKLR1-HA, huCCRL2-HA, and mCCRL2-HA L1.2 transfectants were incubated for 15 min with 100 nM serum form chemerin at the indicated temperature in cell culture media.
Gene_expression (transfectants) of mCCRL2-HA
13) Confidence 0.49 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
For competition binding assays, L1.2 cells transfected with huCCRL2, mCCRL2, or mCMKLR1 were plated into 96-well plates at 0.5 × 106 cells/well.
Gene_expression (transfected) of huCCRL2
14) Confidence 0.49 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
In a general survey of mouse tissues, mCCRL2 is expressed at the RNA level in the lung, heart, and spleen, with minimal expression in the brain or thymus (Fig.
Gene_expression (expressed) of mCCRL2 in heart
15) Confidence 0.49 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.11
isotypes of the resulting rat anti–mouse CCRL2 mAbs, designated BZ5B8 and BZ2E3.


Gene_expression (mAbs) of CCRL2
16) Confidence 0.49 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.15 Pain Relevance 0.14
We conclude that although mast cell–expressed mCCRL2 is not required for the development of IgE-dependent PCA reactions in vivo, mast cell expression of CCRL2 can significantly enhance the local tissue swelling and leukocyte infiltrates associated with such reactions in mice that have been sensitized with relatively low amounts of antigen-specific IgE.


Gene_expression (expression) of CCRL2 in mast cell associated with anaphylaxis and edema
17) Confidence 0.49 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.40 Pain Relevance 0.03
Our data indicate that at some point before 24 h after activation by TLR ligands or proinflammatory cytokines, macrophages can concurrently express both chemerin receptors CMKLR1 and CCRL2.
Gene_expression (express) of CCRL2 in macrophages associated with cytokine
18) Confidence 0.49 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.10
CCRL2 gene expression was normalized to cyclophilin A (cycA) levels in each tissue and displayed relative to CCRL2 expression levels detected in the spleen using the 2???
Gene_expression (levels) of CCRL2 in spleen
19) Confidence 0.49 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.05 Pain Relevance 0
CCRL2 gene expression was normalized to cyclophilin A (cycA) levels in each tissue and displayed relative to CCRL2 expression levels detected in the spleen using the 2???
Gene_expression (expression) of CCRL2 in spleen
20) Confidence 0.49 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.06 Pain Relevance 0

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