INT233497

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 15
Disease Relevance 2.70
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccrl2) plasma membrane (Ccrl2) signal transducer activity (Ccrl2)
Anatomy Link Frequency
macrophages 1
liver 1
brain 1
spleen 1
lungs 1
Ccrl2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 464 95.60 Very High Very High Very High
Bioavailability 14 93.60 High High
cytokine 85 90.48 High High
Inflammation 123 88.64 High High
Multiple sclerosis 15 79.80 Quite High
Inflammatory response 48 62.00 Quite High
Central nervous system 1 50.40 Quite High
Potency 28 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
ketamine 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Edema 266 99.36 Very High Very High Very High
Anaphylaxis 406 98.40 Very High Very High Very High
Contact Dermatitis 98 97.76 Very High Very High Very High
INFLAMMATION 175 88.64 High High
Demyelinating Disease 15 79.80 Quite High
Multiple Sclerosis 15 78.68 Quite High
Hypersensitivity 28 78.00 Quite High
Shock 1 74.40 Quite High
Apoptosis 1 34.32 Quite Low
Mycobacterial Infection 3 27.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (elevated) of Ccrl2
1) Confidence 0.58 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.18
Mast cell–expressed CCRL2 is required for optimal induction of IgE-dependent PCA
Positive_regulation (required) of CCRL2 in Mast cell associated with anaphylaxis
2) Confidence 0.36 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.46 Pain Relevance 0.08
However, CCRL2 was largely dispensable for the tissue swelling associated with FITC-triggered CHS, as both WT and CCRL2 KO mice developed statistically indistinguishable responses (Fig.
Positive_regulation (dispensable) of CCRL2 associated with contact dermatitis and edema
3) Confidence 0.34 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.88 Pain Relevance 0.08
Furthermore, it is interesting to note that CCRL2 and CMKLR1 on macrophages are reciprocally regulated (e.g., LPS causes down-regulation of CMKLR1 but up-regulation of CCRL2 (Fig.
Positive_regulation (regulation) of CCRL2 in macrophages
4) Confidence 0.34 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.11 Pain Relevance 0.08
An analysis of transcription factor binding sites revealed an interferon-stimulated response element (ISRE) upstream of the CCRL2 promoter, which is conserved among mammals and may be responsible for the IFN-?
Positive_regulation (responsible) of CCRL2 promoter
5) Confidence 0.34 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.35 Pain Relevance 0.08
mCMKLR1-HA, huCCRL2-HA, and mCCRL2-HA L1.2 transfectants were incubated for 15 min with 100 nM serum form chemerin at the indicated temperature in cell culture media.
Positive_regulation (incubated) of huCCRL2-HA
6) Confidence 0.32 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
Chemerin inhibits the binding of mAbs specific to amino-terminal epitopes of mCCRL2, implying that chemerin binds directly to the amino-terminal domain of the receptor.
Positive_regulation (epitopes) of mCCRL2
7) Confidence 0.32 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.05
We also tested a panel of known chemoattractants (CCL11, CCL17, CCL22, CCL25, CCL27, CCL28, CXCL9, and CXCL13), as well as protein extracts from homogenized mouse tissues (lungs, kidney, liver, brain, and spleen), and found that none stimulated mCCRL2-dependent chemotaxis in our in vitro transwell chemotaxis assays (unpublished data).
Positive_regulation (stimulated) of mCCRL2 in brain
8) Confidence 0.32 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.12 Pain Relevance 0.04
For direct chemerin binding immunofluorescence assays, mCCRL2-HA, huCCRL2-HA, mCMKLR1-HA, and mCRTH2-HA L1.2 transfectants were incubated for 30 min on ice with 10 nM His8-tagged serum form human chemerin and the indicated concentration of untagged chemerin in binding buffer (PBS with 0.5% BSA and 0.02% azide).
Positive_regulation (incubated) of mCCRL2-HA
9) Confidence 0.32 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
For direct chemerin binding immunofluorescence assays, mCCRL2-HA, huCCRL2-HA, mCMKLR1-HA, and mCRTH2-HA L1.2 transfectants were incubated for 30 min on ice with 10 nM His8-tagged serum form human chemerin and the indicated concentration of untagged chemerin in binding buffer (PBS with 0.5% BSA and 0.02% azide).
Positive_regulation (incubated) of huCCRL2-HA
10) Confidence 0.32 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
mCMKLR1-HA, huCCRL2-HA, and mCCRL2-HA L1.2 transfectants were incubated for 15 min with 100 nM serum form chemerin at the indicated temperature in cell culture media.
Positive_regulation (incubated) of mCCRL2-HA
11) Confidence 0.14 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
We also tested a panel of known chemoattractants (CCL11, CCL17, CCL22, CCL25, CCL27, CCL28, CXCL9, and CXCL13), as well as protein extracts from homogenized mouse tissues (lungs, kidney, liver, brain, and spleen), and found that none stimulated mCCRL2-dependent chemotaxis in our in vitro transwell chemotaxis assays (unpublished data).
Positive_regulation (stimulated) of mCCRL2 in spleen
12) Confidence 0.11 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.12 Pain Relevance 0.04
We also tested a panel of known chemoattractants (CCL11, CCL17, CCL22, CCL25, CCL27, CCL28, CXCL9, and CXCL13), as well as protein extracts from homogenized mouse tissues (lungs, kidney, liver, brain, and spleen), and found that none stimulated mCCRL2-dependent chemotaxis in our in vitro transwell chemotaxis assays (unpublished data).
Positive_regulation (stimulated) of mCCRL2 in liver
13) Confidence 0.11 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.12 Pain Relevance 0.04
We also tested a panel of known chemoattractants (CCL11, CCL17, CCL22, CCL25, CCL27, CCL28, CXCL9, and CXCL13), as well as protein extracts from homogenized mouse tissues (lungs, kidney, liver, brain, and spleen), and found that none stimulated mCCRL2-dependent chemotaxis in our in vitro transwell chemotaxis assays (unpublished data).
Positive_regulation (stimulated) of mCCRL2 in lungs
14) Confidence 0.11 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.12 Pain Relevance 0.04
We also tested a panel of known chemoattractants (CCL11, CCL17, CCL22, CCL25, CCL27, CCL28, CXCL9, and CXCL13), as well as protein extracts from homogenized mouse tissues (lungs, kidney, liver, brain, and spleen), and found that none stimulated mCCRL2-dependent chemotaxis in our in vitro transwell chemotaxis assays (unpublished data).
Positive_regulation (stimulated) of mCCRL2 in kidney
15) Confidence 0.11 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.12 Pain Relevance 0.04

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