INT233500

Context Info Confidence 0.06 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.18 Pain Relevance 0

signal transduction (Tlr4, P2ry1) plasma membrane (Tlr4, P2ry1) mitochondrion (P2ry1) intracellular (Tlr4) signal transducer activity (P2ry1) cytoplasm (Tlr4)

Tlr4 (Mus musculus) P2ry1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 22 6.52 Inflammatory response 12 5.00 agonist 12 5.00 Inflammatory stimuli 8 5.00 adenocard 6 5.00 chemokine 4 5.00 antagonist 4 5.00 cytokine 2 5.00 Central nervous system 2 5.00 Analgesic 2 5.00

Disease Link Frequency Relevance Heat Repression 2 90.56 INFLAMMATION 42 6.52 Mycobacterial Infection 6 5.00 Necrosis 4 5.00 Cancer 4 5.00 Demyelinating Disease 2 5.00 Hypoxia 2 5.00 Apoptosis 2 5.00 Adhesions 2 5.00 Disease 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Figure 3 highlights two examples of regulated GPCR expression: mRNA expression of Gpr84 was induced 10-fold by LPS (6 h) in BMM and 48-fold by LPS (7 h) in TEPM (Figure 3a), whilst P2ry1 was repressed 7-fold by LPS (6 h) in BMM and 18-fold by LPS (7 h) in TEPM (Figure 3b).

LPS Negative_regulation (repressed) of P2ry1

1) Confidence 0.06 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.09 Pain Relevance 0

Figure 3 highlights two examples of regulated GPCR expression: mRNA expression of Gpr84 was induced 10-fold by LPS (6 h) in BMM and 48-fold by LPS (7 h) in TEPM (Figure 3a), whilst P2ry1 was repressed 7-fold by LPS (6 h) in BMM and 18-fold by LPS (7 h) in TEPM (Figure 3b).

LPS Negative_regulation (repressed) of P2ry1

2) Confidence 0.06 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.09 Pain Relevance 0

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