INT233515

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.12
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tnf) extracellular matrix organization (Tnf) carbohydrate metabolic process (Pklr)
cell proliferation (Tnf) cytosol (Pklr) extracellular space (Tnf)
Anatomy Link Frequency
monocyte 3
macrophage 1
Pklr (Mus musculus)
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 12 86.28 High High
Inflammation 22 85.12 High High
IPN 2 51.68 Quite High
Analgesic 2 49.52 Quite Low
adenocard 6 37.44 Quite Low
chemokine 4 25.32 Quite Low
cytokine 2 10.32 Low Low
agonist 12 5.00 Very Low Very Low Very Low
Inflammatory stimuli 8 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 4 100.00 Very High Very High Very High
Cancer 4 100.00 Very High Very High Very High
INFLAMMATION 42 85.88 High High
Mycobacterial Infection 6 74.36 Quite High
Adhesions 2 60.64 Quite High
Inflammatory Pain 2 51.68 Quite High
Demyelinating Disease 2 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PK1 triggered the differentiation of both murine and human bone marrow progenitor cells into the monocyte/macrophage lineage [53], and reprogrammed the response of human monocytes to LPS by amplifying IL-12 and tumor necrosis factor alpha (TNF) production, but inhibiting IL-10 release [53].
PK1 Positive_regulation (amplifying) of Gene_expression (production) of tumor necrosis factor alpha in monocyte associated with necrosis and cancer
1) Confidence 0.05 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.56 Pain Relevance 0.14
PK1 triggered the differentiation of both murine and human bone marrow progenitor cells into the monocyte/macrophage lineage [53], and reprogrammed the response of human monocytes to LPS by amplifying IL-12 and tumor necrosis factor alpha (TNF) production, but inhibiting IL-10 release [53].
PK1 Positive_regulation (amplifying) of in macrophage Gene_expression (production) of tumor necrosis factor alpha in monocyte associated with necrosis and cancer
2) Confidence 0.02 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.56 Pain Relevance 0.14

General Comments

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