INT233517

Context Info Confidence 0.09 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

signal transduction (Tlr4, Gpr85) plasma membrane (Tlr4, Gpr85) intracellular (Tlr4) signal transducer activity (Gpr85) cytoplasm (Tlr4)

Anatomy Link Frequency brain 1 Tlr4 (Mus musculus) Gpr85 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 11 25.52 Inflammatory stimuli 4 21.20 Inflammatory response 6 5.00 agonist 6 5.00 adenocard 3 5.00 chemokine 2 5.00 antagonist 2 5.00 cytokine 1 5.00 Central nervous system 1 5.00 Analgesic 1 5.00

Disease Link Frequency Relevance Heat Disease 1 25.84 INFLAMMATION 21 25.52 Mycobacterial Infection 3 5.00 Necrosis 2 5.00 Cancer 2 5.00 Demyelinating Disease 1 5.00 Hypoxia 1 5.00 Repression 1 5.00 Apoptosis 1 5.00 Adhesions 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, Gpr85 was highly expressed in several macrophage populations and was further up-regulated by LPS, but was also expressed in several regions of the brain (Figure 1a).

LPS Regulation (regulated) of Gpr85 in brain

1) Confidence 0.09 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.