INT23352

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Context Info
Confidence 0.33
First Reported 1981
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 8.35
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (A2M) extracellular space (A2M) extracellular region (A2M)
enzyme binding (A2M)
Anatomy Link Frequency
plasma 2
radial 1
platelet 1
PGE2 1
A2M (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 7 99.64 Very High Very High Very High
Pain 13 99.16 Very High Very High Very High
Fibrositis 6 99.12 Very High Very High Very High
cytokine 10 98.48 Very High Very High Very High
Inflammation 11 98.28 Very High Very High Very High
Abeta 2 97.04 Very High Very High Very High
fibrosis 24 96.04 Very High Very High Very High
cINOD 2 88.92 High High
Angina 3 83.72 Quite High
Chronic pancreatitis 2 82.80 Quite High
Disease Link Frequency Relevance Heat
Wound Healing 2 99.84 Very High Very High Very High
INFLAMMATION 18 99.46 Very High Very High Very High
Necrosis 11 99.44 Very High Very High Very High
Insulin Resistance 4 99.36 Very High Very High Very High
Cancer 141 99.26 Very High Very High Very High
Pain 17 99.16 Very High Very High Very High
Sleep Disorders 4 99.12 Very High Very High Very High
Mixed Connective Tissue Disorder 1 98.40 Very High Very High Very High
Hepatitis 21 98.12 Very High Very High Very High
Alzheimer's Dementia 8 97.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A2M is a protease inhibitor but also has multiple functions as a binding, carrier and targeting protein [40].
Negative_regulation (inhibitor) of A2M
1) Confidence 0.33 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.31 Pain Relevance 0.05
Hypercoagulable states improve through decreased platelet aggregation and adhesion, increased plasminogen activator, increased plasmin, increased antithrombin III, decreased fibrinogen, decreased alpha 2-antiplasmin, decreased alpha 1-antitrypsin, and decreased alpha 2-macroglobulin.
Negative_regulation (decreased) of alpha 2-macroglobulin in platelet associated with adhesions
2) Confidence 0.30 Published 1994 Journal J. Am. Acad. Dermatol. Section Abstract Doc Link 8157787 Disease Relevance 0.94 Pain Relevance 0.07
Dialysate levels of M-PGE2 did not change significantly after glucocorticoid administration, but reduction of masseter resting pain and increase of MVM were associated with decrease of M-PGE2 in the patients with fibromyalgia.
Negative_regulation (decrease) of M-PGE2 in PGE2 associated with pain and fibrositis
3) Confidence 0.22 Published 2002 Journal Acta Odontol. Scand. Section Abstract Doc Link 11902610 Disease Relevance 1.10 Pain Relevance 0.84
Alpha2 macroglobulin (A2M) is a serum protease inhibitor and a major low-density lipoprotein receptor-related protein (LRP) ligand.
Negative_regulation (inhibitor) of A2M
4) Confidence 0.21 Published 2004 Journal Yi Chuan Xue Bao Section Abstract Doc Link 15468911 Disease Relevance 1.10 Pain Relevance 0.23
At the same time, individual fibrinolytic inhibitors (alpha 2-plasmin inhibitor, alpha 1-antitrypsin, alpha 2-macroglobulin, antithrombin-III, and Cl-inactivator) were determined by the radial immunodiffusion method.
Negative_regulation (inhibitor) of alpha 2-macroglobulin in radial
5) Confidence 0.04 Published 1981 Journal Int J Biol Res Pregnancy Section Abstract Doc Link 6916725 Disease Relevance 0.16 Pain Relevance 0
In contrast, the plasma levels of alpha 2-macroglobulin were drastically lowered.
Negative_regulation (lowered) of alpha 2-macroglobulin in plasma
6) Confidence 0.03 Published 1981 Journal Klin. Wochenschr. Section Abstract Doc Link 7019564 Disease Relevance 0.54 Pain Relevance 0.07
They include beta-amyloid protein; the pentraxins C-reactive protein and amyloid P; complement proteins; the inflammatory cytokines interleukin-1, interleukin-6 and tumor necrosis factor-alpha; the protease inhibitors alpha-2-macroglobulin and alpha-1-antichymotrypsin; and the prostaglandin generating cyclooxygenases COX-1 and COX-2.
Negative_regulation (inhibitors) of alpha-2-macroglobulin associated with necrosis, inflammation, cancer, alzheimer's dementia and cytokine
7) Confidence 0.03 Published 2001 Journal Neurobiol. Aging Section Abstract Doc Link 11754986 Disease Relevance 1.23 Pain Relevance 0.30
In 2004, Bachman et al. [2] demonstrated that CO2 insufflation reduces the inflammatory response in rats based on reduced levels of alpha-2 macroglobulin mRNA and beta fibrinogen.
Negative_regulation (reduced) of alpha-2 macroglobulin mRNA associated with inflammatory response
8) Confidence 0.02 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2814196 Disease Relevance 0.91 Pain Relevance 0.16
In these patients the following substances in plasma were determined: Prekallikrein, alpha 2-plasmin inhibitor, alpha 1-antitrypsin, alpha 2-macroglobulin, C1-inactivator, antithrombin-III, plasminogen, fibrinogen, fibrin degradation products (FDP).
Negative_regulation (inhibitor) of alpha 2-macroglobulin in plasma
9) Confidence 0.02 Published 1985 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 2411832 Disease Relevance 0.51 Pain Relevance 0.06
The present study was designed to examine the effects of synthetic serine protease inhibitors (FOY-007 and FOY-305) on proliferation and collagen synthesis of hPFCs under cytokine stimulation.
Spec (examine) Negative_regulation (inhibitors) of FOY-007 associated with cytokine
10) Confidence 0.01 Published 2001 Journal Pancreas Section Abstract Doc Link 11291936 Disease Relevance 0.17 Pain Relevance 0.18
The results showed a significant increase of PAP (p <0.001) and a reduction of alpha2-M (p <0.001) in the group of patients when compared to controls, indicating a degree of fibrinolysis/proteolysis activation.
Negative_regulation (reduction) of alpha2-M
11) Confidence 0.01 Published 2001 Journal Thromb. Haemost. Section Abstract Doc Link 11522015 Disease Relevance 0.37 Pain Relevance 0.22

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