INT233550

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 11
Disease Relevance 4.52
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Clu) extracellular space (Clu) cell death (Clu)
extracellular region (Clu) endoplasmic reticulum (Clu) nucleus (Clu)
Anatomy Link Frequency
nucleus 3
MCF-7 2
Clu (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 5 99.64 Very High Very High Very High
Inflammation 18 50.00 Quite Low
cytokine 31 5.00 Very Low Very Low Very Low
Central nervous system 11 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 23 99.46 Very High Very High Very High
Infection 53 97.32 Very High Very High Very High
Togavirus Infection 75 96.92 Very High Very High Very High
Sprains And Strains 126 96.84 Very High Very High Very High
Cancer 331 96.44 Very High Very High Very High
Apoptosis 215 93.84 High High
Breast Cancer 109 88.08 High High
Metastasis 20 87.56 High High
Reprotox - General 1 37 83.52 Quite High
Stress 40 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some genes related to the inflammatory response, such as Cxcl10, Clu and antigen presentation, such as B2m, Fcer1g showed over-expression only at 72 and 96 hr post infection (Fig 2).
Localization (presentation) of Clu associated with inflammatory response and infection
1) Confidence 0.69 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 0.90 Pain Relevance 0.05
We next performed immunohistochemistry to determine the cellular localization of clusterin expression.
Spec (determine) Localization (localization) of clusterin
2) Confidence 0.60 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.75 Pain Relevance 0
The chimeric GFP tagged clusterin protein is excluded from the nucleus and is localized within the endomembrane system, as indicated by the punctate fluorescence, rather than the diffuse staining typical of cytoplasmic localization (Figure 1 panel D).
Localization (localized) of clusterin in nucleus
3) Confidence 0.55 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0 Pain Relevance 0
The retro-translocation of clusterin from the endomembrane system to the cytoplasm has recently been confirmed [42], providing an important missing component in the biosynthesis of the disulfide linked nuclear isoform.
Localization (translocation) of clusterin
4) Confidence 0.55 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.19 Pain Relevance 0
Clusterin is a secreted heterodimeric 70-80 kDa glycoprotein composed of alpha and beta chains linked by five inter-chain disulfide bonds [4,5].
Localization (secreted) of Clusterin
5) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.68 Pain Relevance 0
It is also important to recognize that parental MCF-7 cells also secrete measurable levels of clusterin over the 48 h collection time.
Localization (secrete) of clusterin in MCF-7
6) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0 Pain Relevance 0
This is reflected by a substantial increase in the levels of extracellular clusterin (Figure 1 panel B), however since it is not possible to normalize the levels of extracellular clusterin, it is only possible to state that the transfected cell line secretes approximately 10-15 times more clusterin than the untransfected, unstressed MCF-7 cells.
Localization (secretes) of clusterin in MCF-7
7) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0 Pain Relevance 0
In our view it is more likely that secretory clusterin plays one or more distinct roles in the metastatic spread of the cells from the primary tumor.
Localization (secretory) of clusterin associated with cancer
8) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.65 Pain Relevance 0
While the experimental design used in this study cannot exclude the possibility that some of the clusterin synthesized within the endomembrane system is retro-translocated to the nucleus even in the unstressed cells over-expressing the secretory isoform, we were unable to detect any nuclear clusterin prior to treatment with TNFalpha or tamoxifen (Figure 1D and data not shown).
Localization (detect) of clusterin in nucleus
9) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.43 Pain Relevance 0
Targeting the secreted form of clusterin may decrease the rate of metastatic progression.


Localization (secreted) of clusterin
10) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.43 Pain Relevance 0
While the experimental design used in this study cannot exclude the possibility that some of the clusterin synthesized within the endomembrane system is retro-translocated to the nucleus even in the unstressed cells over-expressing the secretory isoform, we were unable to detect any nuclear clusterin prior to treatment with TNFalpha or tamoxifen (Figure 1D and data not shown).
Localization (translocated) of clusterin in nucleus
11) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.48 Pain Relevance 0

General Comments

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