INT233551

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Context Info
Confidence 0.74
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 12.25
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apod) transport (Apod) extracellular space (Apod)
extracellular region (Apod) endoplasmic reticulum (Apod) intracellular (Apod)
Anatomy Link Frequency
epithelium 4
leukocyte 1
neurons 1
smooth muscle cell 1
Apod (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 2 99.98 Very High Very High Very High
Multiple sclerosis 246 98.96 Very High Very High Very High
Inflammation 155 98.88 Very High Very High Very High
chemokine 24 93.84 High High
Inflammatory response 14 89.80 High High
intrathecal 4 88.92 High High
cytokine 28 83.92 Quite High
glial activation 2 79.68 Quite High
Demyelination 6 65.44 Quite High
anesthesia 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 56 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 32 100.00 Very High Very High Very High
Prostate Cancer 167 99.36 Very High Very High Very High
Demyelinating Disease 252 98.96 Very High Very High Very High
Cancer 377 98.90 Very High Very High Very High
INFLAMMATION 169 98.88 Very High Very High Very High
Aging 261 98.76 Very High Very High Very High
Disease 83 95.52 Very High Very High Very High
Starvation 5 90.72 High High
Neurodegenerative Disease 9 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies of prostate cancer have demonstrated elevated APOD protein levels in prostate intraepithelial neoplasia and prostate carcinoma [29], but associations between APOD polymorphisms, or APOD expression in benign epithelium in the context of cancer phenotypes have not been reported.
Gene_expression (expression) of APOD in epithelium associated with cancer and prostate cancer
1) Confidence 0.74 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 1.59 Pain Relevance 0
Two recent studies of the Drosophila ApoD ortholog, GLaz, provide context for the potential influence of ApoD expression on cytoprotection and cell survival [30,31].
Gene_expression (expression) of ApoD
2) Confidence 0.74 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 1.74 Pain Relevance 0
Studies of prostate cancer have demonstrated elevated APOD protein levels in prostate intraepithelial neoplasia and prostate carcinoma [29], but associations between APOD polymorphisms, or APOD expression in benign epithelium in the context of cancer phenotypes have not been reported.
Gene_expression (polymorphisms) of APOD in epithelium associated with cancer and prostate cancer
3) Confidence 0.64 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 1.54 Pain Relevance 0
Six genes expressed relatively highly in FVB/N prostates (for example, ApoD) exhibited significantly higher transcript levels in the prostates containing high-grade cancers relative to prostates with low-grade cancer (Figure 5).
Gene_expression (expressed) of ApoD associated with cancer
4) Confidence 0.64 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 1.19 Pain Relevance 0
In the absence of infiltrating lymphocytes and neutrophils in the prostates of these mice, we confirmed that age-associated changes in smooth muscle cell histology and aging-associated gene expression occurred (e.g. 2-fold increase in Apod expression; p<0.05) (Supporting Information Figure S3).
Gene_expression (expression) of Apod in smooth muscle cell associated with aging
5) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.98 Pain Relevance 0
For example, the gene encoding apolipoprotein D, which is known to enhance resistance to cell stress, was expressed at significantly greater levels in benign epithelium associated with high-grade versus low-grade cancers.


Gene_expression (expressed) of apolipoprotein D in epithelium associated with stress, cancer and disorder of lipid metabolism
6) Confidence 0.58 Published 2007 Journal Genome Biol Section Abstract Doc Link PMC2394769 Disease Relevance 0.84 Pain Relevance 0
We also determined that Apod and Ccl8 are expressed at very low levels in white blood cell isolates and in microdissected epithelium relative to stroma, and no differences were seen between young and old epithelium.
Gene_expression (expressed) of Apod in epithelium
7) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.27 Pain Relevance 0.08
However, the fact that Ccl8 and Apod were not expressed in the peripheral leukocyte populations isolated from young and old C57BL/6 mice, suggests that these alterations are likely to be intrinsic to the smooth muscle cells and fibroblasts.


Neg (not) Gene_expression (expressed) of Apod in leukocyte
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.77 Pain Relevance 0.33
Of relevance to the gene expression measurements, collagen fragmentation has been shown to promote oxidative stress [44] and could explain the increased expression of stress response genes, such as Apod as well as the increase in inflammatory infiltrates.
Gene_expression (expression) of Apod associated with stress and inflammation
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.97 Pain Relevance 0.15
In the central nervous system apolipoprotein D is a lipocalin that is mainly expressed in glia, but also in neurons.
Gene_expression (expressed) of apolipoprotein D in neurons associated with central nervous system and disorder of lipid metabolism
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.33 Pain Relevance 0.46
In the two comparisons of both MScl types with the control group, several proteins are present in both comparisons, for example Ig gamma-1 chain C region and apolipoprotein D.
Gene_expression (present) of apolipoprotein D associated with multiple sclerosis and disorder of lipid metabolism
11) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.03 Pain Relevance 0.39

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