INT233552

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 19
Disease Relevance 9.31
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Clu) extracellular space (Clu) cell death (Clu)
extracellular region (Clu) endoplasmic reticulum (Clu) nucleus (Clu)
Anatomy Link Frequency
MCF-7 18
microglia 2
Clu (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 18 92.08 High High
cytokine 55 91.32 High High
chemokine 5 67.80 Quite High
Central nervous system 11 41.60 Quite Low
anesthesia 19 5.00 Very Low Very Low Very Low
imagery 17 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 563 99.84 Very High Very High Very High
Apoptosis 391 99.68 Very High Very High Very High
Reprotox - General 1 69 98.32 Very High Very High Very High
Death 155 97.28 Very High Very High Very High
Togavirus Infection 75 95.28 Very High Very High Very High
Infection 53 94.88 High High
INFLAMMATION 23 92.08 High High
Prostate Cancer 27 90.88 High High
Stress 72 90.24 High High
Shock 17 86.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously shown that clusterin expression is increased in tumors developing in mice with a prostate specific deletion of the Pten tumor suppressor gene [23].
Positive_regulation (increased) of Gene_expression (expression) of clusterin associated with cancer
1) Confidence 0.59 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.76 Pain Relevance 0
While the synthesis of clusterin and the appearance of the nuclear isoform is clearly upregulated during apoptosis, the role of the secretory protein in either cell death or cell survival has not been clearly delineated.
Positive_regulation (upregulated) of Gene_expression (synthesis) of clusterin associated with apoptosis and death
2) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.82 Pain Relevance 0
Thus, while the protein is clearly expressed in cells that are destined to undergo apoptosis, the observation that high levels of clusterin expression is also seen in surviving cells suggests that it may play a role in cell survival.
Positive_regulation (levels) of Gene_expression (expression) of clusterin associated with apoptosis
3) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 1.05 Pain Relevance 0.05
Clu-activated microglia showed increased MHC class II expression, secreted reactive nitrogen intermediates and TNF-?
Positive_regulation (increased) of Gene_expression (expression) of Clu in microglia
4) Confidence 0.46 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.49 Pain Relevance 0.36
In MCF-7 cells, during apoptosis induced by TNFalpha or anti-estrogen treatment, clusterin expression is significantly upregulated [12].
Positive_regulation (upregulated) of Gene_expression (expression) of clusterin in MCF-7 associated with apoptosis
5) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.18 Pain Relevance 0
Elevated clusterin expression generally correlates with tumor grade in prostate cancer [27-29], although at least one report has shown that the level of clusterin mRNA in prostate cancer is lower than in paired benign tissue from the organ [30].
Positive_regulation (Elevated) of Gene_expression (expression) of clusterin associated with cancer and reprotox - general 1
6) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 1.25 Pain Relevance 0.04
Over-expression of clusterin or other secretory proteins does not appear to induce an ER-overload response [38], and it is unlikely that the glycosylation, processing or trafficking of the glycoprotein is altered as a consequence of over-expression.
Positive_regulation (induce) of Gene_expression (expression) of clusterin
7) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.24 Pain Relevance 0
Over-expression of this clusterin isoform, which binds to Ku70/80 has been shown to induce apoptosis in MCF-7 cells [13].
Positive_regulation (expression) of Gene_expression (-) of clusterin isoform in MCF-7 associated with apoptosis
8) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.27 Pain Relevance 0
Over-expression of clusterin
Positive_regulation (Over) of Gene_expression (expression) of clusterin
9) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.48 Pain Relevance 0
Over-expression of this clusterin isoform, which binds to Ku70/80 has been shown to induce apoptosis in MCF-7 cells [13].
Positive_regulation (expression) of Gene_expression (expression) of clusterin isoform in MCF-7 associated with apoptosis
10) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.27 Pain Relevance 0
Over-expression of this clusterin isoform, which binds to Ku70/80 has been shown to induce apoptosis in MCF-7 cells [13].
Positive_regulation (Over) of Gene_expression (-) of clusterin isoform in MCF-7 associated with apoptosis
11) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.27 Pain Relevance 0
The intracellular levels of clusterin in the MCF-7 CLU cell line is increased between 10-15 fold by 48 h compared to the parental line (Figure 1 panels B and C).
Positive_regulation (increased) of Gene_expression (levels) of clusterin in MCF-7
12) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.11 Pain Relevance 0
Over-expression of clusterin
Positive_regulation (-) of Gene_expression (expression) of clusterin
13) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.48 Pain Relevance 0
Over-expression of this clusterin isoform, which binds to Ku70/80 has been shown to induce apoptosis in MCF-7 cells [13].
Positive_regulation (Over) of Gene_expression (expression) of clusterin isoform in MCF-7 associated with apoptosis
14) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.27 Pain Relevance 0
Over-expression of this clusterin isoform, which binds to Ku70/80 has been shown to induce apoptosis in MCF-7 cells [13].
Positive_regulation (Over) of Gene_expression (Over) of clusterin isoform in MCF-7 associated with apoptosis
15) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.27 Pain Relevance 0
Over-expression of clusterin
Positive_regulation (expression) of Gene_expression (expression) of clusterin
16) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.48 Pain Relevance 0
Over-expression of this clusterin isoform, which binds to Ku70/80 has been shown to induce apoptosis in MCF-7 cells [13].
Positive_regulation (expression) of Gene_expression (Over) of clusterin isoform in MCF-7 associated with apoptosis
17) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.27 Pain Relevance 0
Stable transfection of secretory clusterin abrogates the effects of TNFalpha and tamoxifen on cell cycle kinetics and apoptosis in MCF-7CLU cells, resulting in the overall increase in cell number (Figure 2 panel A).
Positive_regulation (transfection) of Gene_expression (transfection) of clusterin associated with apoptosis
18) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.28 Pain Relevance 0
This is reflected by a substantial increase in the levels of extracellular clusterin (Figure 1 panel B), however since it is not possible to normalize the levels of extracellular clusterin, it is only possible to state that the transfected cell line secretes approximately 10-15 times more clusterin than the untransfected, unstressed MCF-7 cells.
Positive_regulation (increase) of Gene_expression (levels) of clusterin in MCF-7
19) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.05 Pain Relevance 0

General Comments

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