INT233554

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.96
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Clu) extracellular space (Clu) cell death (Clu)
extracellular region (Clu) endoplasmic reticulum (Clu) nucleus (Clu)
Clu (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 5 99.64 Very High Very High Very High
Inflammation 18 50.00 Quite Low
Central nervous system 11 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
fifth nerve 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 53 100.00 Very High Very High Very High
INFLAMMATION 23 99.46 Very High Very High Very High
Apoptosis 39 99.00 Very High Very High Very High
Togavirus Infection 75 96.92 Very High Very High Very High
Sprains And Strains 126 96.84 Very High Very High Very High
Cancer 99 82.16 Quite High
Prostate Cancer 27 68.48 Quite High
Disease 13 67.88 Quite High
Death 11 49.12 Quite Low
Urological Neuroanatomy 2 19.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some genes related to the inflammatory response, such as Cxcl10, Clu and antigen presentation, such as B2m, Fcer1g showed over-expression only at 72 and 96 hr post infection (Fig 2).
Negative_regulation (infection) of Gene_expression (expression) of Clu associated with inflammatory response and infection
1) Confidence 0.39 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 0.92 Pain Relevance 0.05
We next performed immunohistochemistry to determine the cellular localization of clusterin expression.
Spec (determine) Negative_regulation (localization) of Gene_expression (expression) of clusterin
2) Confidence 0.36 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.76 Pain Relevance 0
Stable transfection of secretory clusterin abrogates the effects of TNFalpha and tamoxifen on cell cycle kinetics and apoptosis in MCF-7CLU cells, resulting in the overall increase in cell number (Figure 2 panel A).
Negative_regulation (abrogates) of Gene_expression (transfection) of clusterin associated with apoptosis
3) Confidence 0.25 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.28 Pain Relevance 0

General Comments

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