INT233555

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 4.12
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) extracellular region (Cxcl12) plasma membrane (Cxcl12)
Cxcl12 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 84 75.00 Quite High
Hippocampus 1 62.72 Quite High
imagery 16 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 140 100.00 Very High Very High Very High
Metastasis 102 100.00 Very High Very High Very High
Repression 20 99.68 Very High Very High Very High
Sprains And Strains 124 97.36 Very High Very High Very High
Carcinoma 100 97.24 Very High Very High Very High
Colon Cancer 100 94.76 High High
Apoptosis 185 94.68 High High
Hyperplasia 4 93.04 High High
Disease 11 86.32 High High
Bordatella Infection 12 75.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, we determined that Bim knockdown had little to no effect on cellular adherence in CXCL12 or wild-type cells compared to untransduced (mock) parental cells suggesting Bim is not regulating focal adhesions (Figure 6E).
Neg (no) Regulation (effect) of CXCL12 associated with adhesions
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.51 Pain Relevance 0
CXCL12 expression and adhesion are unaffected by Bim repression
Neg (unaffected) Regulation (unaffected) of CXCL12 associated with repression and adhesions
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.51 Pain Relevance 0
The objective of these studies was to define the signaling mechanisms regulating CXCL12-mediated anoikis.


Regulation (regulating) of CXCL12-mediated
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943927 Disease Relevance 1.10 Pain Relevance 0.04
It is tempting to postulate that CXCL12 is a novel extracellular regulator of Bak and that this signaling axis is important in normal epithelial turnover.
Regulation (regulator) of CXCL12
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.96 Pain Relevance 0.06
Several genes exhibiting strain-dependent differences in prostate expression have been studied in the context of prostate development (for example, Sbp), androgen regulation (Fabp5, Odc), tumorigenesis (for example, Psca, Azgp1, Apod, Mmp7, Egf, Mgst1, Clusterin), and the progression of metastatic cancer (Cxcl12, B2m, H2 family members) [8].
Regulation (regulation) of Cxcl12 associated with sprains and strains and metastasis
5) Confidence 0.22 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 1.04 Pain Relevance 0.03

General Comments

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